Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599667 | 0.93 | ATM (0.37) | HTTTSHRSMN1; SMN2 | |
| SCHEMBL5781243 | 0.90 | CYP1A2 (0.36) | HSD11B1CYP2C9CYP2C19LMNAKMT2A | |
| SCHEMBL5778222 | 0.89 | SMYD3 (0.34) | HTTTSHRSMYD3LMNAOPRM1 | |
| SCHEMBL5784794 | 0.88 | RXFP1 (0.42) | CYP2C9CYP2C19MAPK14MEN1KMT2A | |
| SCHEMBL5783958 | 0.86 | PAX8 (0.41) | SMYD3 | |
| SCHEMBL5599757 | 0.85 | SIGMAR1 (0.40) | HTTTSHRCYP2C9CYP2C19MAPK14 | |
| SCHEMBL5599317 | 0.83 | GNRHR (0.34) | HTTTSHRSMYD3 | |
| SCHEMBL5783811 | 0.83 | HTT (0.36) | HTTTSHRSMYD3HSD11B1CYP2C9 | |
| SCHEMBL5780422 | 0.83 | P2RX7 (0.36) | CYP2C19ALDH1A1 | |
| SCHEMBL5786885 | 0.82 | GNRHR (0.33) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |