Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784794 | 0.85 | RXFP1 (0.42) | TP53DRD2CYP2C9CYP2C19MAPK14 | |
| SCHEMBL5599482 | 0.85 | HTT (0.37) | ALDH1A1SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL5599667 | 0.83 | ATM (0.37) | SMN1; SMN2DRD2HTTTSHRHTR1A | |
| SCHEMBL5786199 | 0.81 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1SMN1; SMN2TP53THRB | |
| SCHEMBL5783958 | 0.80 | PAX8 (0.41) | TP53 | |
| SCHEMBL5781243 | 0.79 | CYP1A2 (0.36) | TP53LMNACYP2C9CYP2C19 | |
| SCHEMBL5786887 | 0.77 | GNRHR (0.41) | DRD2 | |
| SCHEMBL5781865 | 0.76 | BCHE (0.36) | ALDH1A1MAPTTSHROPRM1 | |
| SCHEMBL5782925 | 0.76 | LMNA (0.39) | SIGMAR1ALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL5778222 | 0.76 | SMYD3 (0.34) | SIGMAR1ALDH1A1LMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |