Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599670 | 0.70 | CYP2C19 (0.44) | MEN1KMT2AMAPTALDH1A1MAOB | |
| SCHEMBL5578971 | 0.69 | SIGMAR1 (0.48) | MEN1KMT2AMAPTALDH1A1HTT | |
| Hydrochloric Acid SCHEMBL7007458 | 0.66 | NPY5R (0.49) | ALDH1A1L3MBTL1POLBCYP1A2CYP2D6 | |
| SCHEMBL5599673 | 0.66 | POLB (0.46) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL2300428 | 0.64 | MAPT (0.47) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL4016784 | 0.64 | ALDH1A1 (0.73) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7258861 | 0.64 | GAA (0.74) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL7249256 | 0.63 | FAAH (0.75) | MEN1KMT2AMAPTHTTLMNA | |
| SCHEMBL15308418 | 0.62 | MEN1 (0.78) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL15306500 | 0.61 | NAMPT (0.72) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |