Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5782306 | 0.93 | HTR2A (0.40) | HCRTR1HCRTR2HTR2AHTR2CGNRHR | |
| SCHEMBL5783985 | 0.89 | DPP4 (0.34) | HTR2AHTR2CGNRHRKCNH2DPP4 | |
| SCHEMBL5599358 | 0.89 | PARP1 (0.36) | CHRM1GNRHRKCNH2DPP4KDM1A | |
| SCHEMBL5599374 | 0.87 | GNRHR (0.40) | P2RX7CHRM1GNRHRKCNH2PSEN1 | |
| SCHEMBL5599389 | 0.87 | GNRHR (0.40) | P2RX7CHRM1GNRHRKCNH2PSEN1 | |
| SCHEMBL5780422 | 0.86 | P2RX7 (0.36) | P2RX7HCRTR1HCRTR2HPGDGNRHR | |
| SCHEMBL5599242 | 0.86 | CYP3A4 (0.38) | GNRHRKCNH2CYP2D6ALDH1A1CYP2C19 | |
| SCHEMBL5782925 | 0.85 | LMNA (0.39) | HCRTR1HCRTR2ALDH1A1CYP2C19 | |
| SCHEMBL5599710 | 0.84 | GLA (0.37) | CHRM1GNRHRKCNH2ALOX15CRHR1 | |
| SCHEMBL5780537 | 0.84 | P2RX7 (0.40) | P2RX7HCRTR1HCRTR2HPGDGNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |