Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5600002 | 0.93 | P2RX7 (0.37) | HTR2AHTR2CCYP2C19GNRHRKCNH2 | |
| SCHEMBL5783985 | 0.92 | DPP4 (0.34) | HTR2AHTR2CGNRHRKCNH2DPP4 | |
| SCHEMBL5599358 | 0.92 | PARP1 (0.36) | GNRHRKCNH2DPP4PSEN1PSEN2 | |
| SCHEMBL5599374 | 0.91 | GNRHR (0.40) | CYP2C9CYP2C19MAPK14HSD11B1GNRHR | |
| SCHEMBL5599389 | 0.91 | GNRHR (0.40) | CYP2C9CYP2C19MAPK14HSD11B1GNRHR | |
| SCHEMBL5782925 | 0.89 | LMNA (0.39) | CYP2C9CYP2C19MAPK14HSD11B1HTT | |
| SCHEMBL5599710 | 0.86 | GLA (0.37) | GNRHRKCNH2HTTLMNANR3C2 | |
| SCHEMBL5599242 | 0.85 | CYP3A4 (0.38) | CYP2C9CYP2C19HSD11B1GNRHRKCNH2 | |
| SCHEMBL5783469 | 0.83 | ALDH1A1 (0.47) | CYP2C9SMYD3GNRHRKCNH2LMNA | |
| SCHEMBL5784243 | 0.83 | GNRHR (0.42) | HTR2AHTR2CSMYD3HSD11B1GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |