Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599389 | 0.86 | GNRHR (0.40) | GNRHRKCNH2RXFP1HSD11B1P2RX7 | |
| SCHEMBL5599374 | 0.86 | GNRHR (0.40) | GNRHRKCNH2RXFP1HSD11B1P2RX7 | |
| SCHEMBL5786887 | 0.85 | GNRHR (0.41) | GNRHRKCNH2RXFP1HSD11B1P2RX7 | |
| SCHEMBL5599203 | 0.85 | GNRHR (0.39) | GNRHRKCNH2RXFP1HSD11B1P2RX7 | |
| SCHEMBL5599816 | 0.81 | TP53 (0.38) | GNRHRKCNH2SMYD3MEN1KMT2A | |
| SCHEMBL5599382 | 0.81 | AGTR2 (0.36) | GNRHRKCNH2MEN1KMT2A | |
| SCHEMBL5782306 | 0.77 | HTR2A (0.40) | GNRHRKCNH2SMYD3HSD11B1 | |
| SCHEMBL5782925 | 0.76 | LMNA (0.39) | HSD11B1MEN1KMT2A | |
| SCHEMBL5599289 | 0.75 | DRD2 (0.37) | GNRHRKCNH2SMYD3P2RX7HPGD | |
| SCHEMBL5784243 | 0.75 | GNRHR (0.42) | GNRHRKCNH2SMYD3HSD11B1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |