Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 5/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599702 | 0.79 | HSD11B1 (0.35) | OPRM1 | |
| SCHEMBL5578683 | 0.67 | HDAC1 (0.52) | — | |
| SCHEMBL5599822 | 0.67 | NOTUM (0.52) | — | |
| SCHEMBL5578876 | 0.66 | SIGMAR1 (0.44) | — | |
| SCHEMBL5599346 | 0.65 | KMT2A (0.37) | OPRD1OPRK1OPRM1 | |
| SCHEMBL4116754 | 0.63 | ACE (0.35) | — | |
| SCHEMBL5599390 | 0.63 | KDM2B (0.42) | — | |
| SCHEMBL5599280 | 0.63 | KCNA3 (0.34) | — | |
| SCHEMBL3994423 | 0.63 | DPP9 (0.35) | OPRM1 | |
| SCHEMBL6950655 | 0.62 | OPRD1 (1.00) | OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |