Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.80 |
| ▸ | CA4 | P22748 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL23116337 | 1.00 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL21633477 | 1.00 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL5278984 | 0.95 | CA1 (0.73) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL37009 | 0.95 | CA1 (0.89) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL5081259 | 0.95 | CA1 (0.89) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL25312642 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL21752953 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL25170206 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL21848043 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 | |
| Acetic Acid SCHEMBL21752943 | 0.90 | CA1 (0.80) | CA1CA4LMNATSHRFFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170312313-A1 | SYNTHESIS OF ULTRA-SMALL CERIA-ZIRCONIA NANOPARTICLES AND CERIA-ZIRCONIA NANO COMPLEX AND ITS APPLICATION AS A THERAPEUTIC AGENT FOR SEPSIS | SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) | 2017-11-02 | — | — | US | claimed |
| US-6657068-B2 | To halophthalic acid in presence of sources of cobalt, manganese, zirconium, hafnium, and/or bromide; imidation copolymerization to polyetherimides | GENERAL ELECTRIC COMPANY | 2003-12-02 | — | — | US | claimed |
| US-6657067-B2 | Oxidation of 4-chloro-o-xylene in acetic acid and presence of sources of cobalt, manganese, zirconium, hafnium, and/or bromide to form chlorophthalic acid; copolymerizing to polyetherimides; imidation | GENERAL ELECTRIC COMPANY | 2003-12-02 | — | — | US | claimed |
| US-6649773-B2 | Liquid phase oxidation of halo-ortho-xylene in acetic acid using catalyst containing cobalt, manganese, zirconium and/or hafnium, and bromide at elevated temperature and pressure, dehydrating halophthalic acid formed to anhydride | GENERAL ELECTRIC COMPANY | 2003-11-18 | — | — | US | claimed |
| US-20030181758-A1 | METHOD FOR THE MANUFACTURE OF HALOPHTHALIC ACIDS AND ANHYDRIDES | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2003-09-25 | — | — | US | claimed |
| US-20030181757-A1 | LIQUID PHASE OXIDATION OF HALOGENATED ORTHO-XYLENES | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2003-09-25 | — | — | US | claimed |
| US-20030181756-A1 | METHOD FOR THE MANUFACTURE OF CHLOROPHTHALIC ANHYDRIDE | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2003-09-25 | — | — | US | claimed |
| US-20170312313-A1 | SYNTHESIS OF ULTRA-SMALL CERIA-ZIRCONIA NANOPARTICLES AND CERIA-ZIRCONIA NANO COMPLEX AND ITS APPLICATION AS A THERAPEUTIC AGENT FOR SEPSIS | SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION (KR) | 2017-11-02 | — | — | US | disclosed |
| EP-1490318-B1 | LIQUID PHASE OXIDATION OF HALOGENATED ORTHO-XYLENES | GEN ELECTRIC (US) | 2007-11-21 | — | — | EP | disclosed |
| CN-100334059-C | Liquid Phase Oxidation of Halogenated Ortho-Xylene | GEN ELECTRIC (US) | 2007-08-29 | — | — | CN | disclosed |
| CN-1653028-A | Liquid phase oxidation of halogenated ortho-xylenes | GEN ELECTRIC (US) | 2005-08-10 | — | — | CN | disclosed |
| EP-1490318-A1 | LIQUID PHASE OXIDATION OF HALOGENATED ORTHO-XYLENES | GENERAL ELECTRIC COMPANY (US) | 2004-12-29 | — | — | EP | disclosed |
| US-6657068-B2 | To halophthalic acid in presence of sources of cobalt, manganese, zirconium, hafnium, and/or bromide; imidation copolymerization to polyetherimides | GENERAL ELECTRIC COMPANY | 2003-12-02 | — | — | US | disclosed |
| US-6657067-B2 | Oxidation of 4-chloro-o-xylene in acetic acid and presence of sources of cobalt, manganese, zirconium, hafnium, and/or bromide to form chlorophthalic acid; copolymerizing to polyetherimides; imidation | GENERAL ELECTRIC COMPANY | 2003-12-02 | — | — | US | disclosed |
| US-6649773-B2 | Liquid phase oxidation of halo-ortho-xylene in acetic acid using catalyst containing cobalt, manganese, zirconium and/or hafnium, and bromide at elevated temperature and pressure, dehydrating halophthalic acid formed to anhydride | GENERAL ELECTRIC COMPANY | 2003-11-18 | — | — | US | disclosed |
| WO-2003082791-A1 | LIQUID PHASE OXIDATION OF HALOGENATED ORTHO-XYLENES | GENERAL ELECTRIC COMPANY (US) | 2003-10-09 | — | — | WO | disclosed |
| US-20030181758-A1 | METHOD FOR THE MANUFACTURE OF HALOPHTHALIC ACIDS AND ANHYDRIDES | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2003-09-25 | — | — | US | disclosed |
| US-20030181757-A1 | LIQUID PHASE OXIDATION OF HALOGENATED ORTHO-XYLENES | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2003-09-25 | — | — | US | disclosed |
| US-20030181756-A1 | METHOD FOR THE MANUFACTURE OF CHLOROPHTHALIC ANHYDRIDE | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2003-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030181757-A1 | LIQUID PHASE OXIDATION OF HALOGENATED ORTHO-XYLENES | HPD, XDH, HAO2 | CA1 379/4885CA4 242/4885LMNA 1360/4885 |
| US-20030181756-A1 | METHOD FOR THE MANUFACTURE OF CHLOROPHTHALIC ANHYDRIDE | CBX4, HPD, PPOX | CA1 48/4885CA4 12/4885LMNA 3750/4885 |
| US-20030181758-A1 | METHOD FOR THE MANUFACTURE OF HALOPHTHALIC ACIDS AND ANHYDRIDES | HPD, HAAO, HAO2 | CA1 25/4885CA4 17/4885LMNA 2216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.