Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975725 | 0.84 | NUDT1 (0.53) | L3MBTL1TDP1NUDT1HSD17B10ALDH1A1 | |
| SCHEMBL4703657 | 0.81 | TDP1 (0.58) | L3MBTL1TDP1NUDT1HSD17B10ALDH1A1 | |
| SCHEMBL28263786 | 0.81 | L3MBTL1 (0.66) | L3MBTL1TDP1ATMCHRNA7PDE5A | |
| SCHEMBL2534009 | 0.80 | TDP1 (0.69) | L3MBTL1TDP1ALDH1A1ATMCHRNA7 | |
| SCHEMBL18943805 | 0.80 | TDP1 (0.65) | L3MBTL1TDP1NUDT1HSD17B10ALDH1A1 | |
| SCHEMBL30013732 | 0.80 | TDP1 (0.69) | L3MBTL1TDP1ALDH1A1ATMCHRNA7 | |
| SCHEMBL30013876 | 0.80 | TDP1 (0.60) | L3MBTL1TDP1APPATMCHRNA7 | |
| Hydrochloric Acid SCHEMBL23063743 | 0.77 | NUDT1 (0.49) | L3MBTL1TDP1NUDT1HSD17B10ALDH1A1 | |
| SCHEMBL6968387 | 0.76 | ALDH1A1 (0.51) | NUDT1HSD17B10ALDH1A1CYP1A2HPGD | |
| SCHEMBL6976291 | 0.75 | LMNA (0.55) | L3MBTL1NUDT1HSD17B10ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102068434-B | Application of 4-(cyclohexyl)-aminoquinazoline compounds | ZHIHUA LIN | 2012-08-22 | — | — | CN | disclosed |
| CN-102068434-B | Application of 4-(cyclohexyl)-aminoquinazoline compounds | ZHIHUA LIN | 2012-08-22 | — | — | CN | disclosed |
| CN-102068434-B | Application of 4-(cyclohexyl)-aminoquinazoline compounds | ZHIHUA LIN | 2012-08-22 | — | — | CN | disclosed |
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| CN-102068434-A | Application of 4-(cyclohexyl)-aminoquinazoline compounds | ZHIHUA LIN | 2011-05-25 | — | — | CN | disclosed |
| CN-102068434-A | Application of 4-(cyclohexyl)-aminoquinazoline compounds | ZHIHUA LIN | 2011-05-25 | — | — | CN | disclosed |
| CN-102068434-A | Application of 4-(cyclohexyl)-aminoquinazoline compounds | ZHIHUA LIN | 2011-05-25 | — | — | CN | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | L3MBTL1 2693/4885TDP1 3716/4885NUDT1 3442/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | L3MBTL1 2693/4885TDP1 3716/4885NUDT1 3442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.