Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23063743 | 0.90 | NUDT1 (0.49) | NUDT1HSD17B10ALDH1A1CYP1A2HPGD | |
| SCHEMBL560134 | 0.84 | L3MBTL1 (0.65) | NUDT1HSD17B10ALDH1A1CYP1A2HPGD | |
| SCHEMBL6974797 | 0.80 | ACHE (0.48) | KMT2AHRH4BCHEACHEMAOB | |
| SCHEMBL19297014 | 0.78 | TLR7 (0.51) | ALDH1A1CYP1A2L3MBTL1TDP1KMT2A | |
| SCHEMBL6981676 | 0.76 | JUND (0.46) | HSD17B10ALDH1A1MEN1KMT2AHRH4 | |
| SCHEMBL5314315 | 0.75 | DCPS (0.47) | NUDT1HSD17B10ALDH1A1CYP1A2HPGD | |
| SCHEMBL20389878 | 0.75 | CYP1A2 (0.62) | HSD17B10ALDH1A1CYP1A2APPKDM4E | |
| SCHEMBL30735510 | 0.74 | MEN1 (0.43) | CYP1A2L3MBTL1TDP1SLC18A3SIGMAR1 | |
| SCHEMBL4962813 | 0.74 | MEN1 (0.43) | CYP1A2L3MBTL1TDP1SLC18A3SIGMAR1 | |
| SCHEMBL11738690 | 0.74 | TDP1 (0.42) | L3MBTL1TDP1SLC18A3SIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-B1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2003-01-08 | — | — | EP | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |