Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.59 |
| ▸ | MME | P08473 | 2/20 | 0.59 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.56 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650610 | 1.00 | ACE (0.59) | ACEMMEMMEL1NAALAD2 | |
| SCHEMBL391211 | 1.00 | ACE (0.59) | ACEMMEMMEL1NAALAD2 | |
| SCHEMBL7380315 | 0.95 | MMEL1 (0.64) | ACEMMEMMEL1 | |
| SCHEMBL7385743 | 0.95 | MMEL1 (0.64) | ACEMMEMMEL1 | |
| SCHEMBL11296564 | 0.92 | ATM (0.52) | ACEMMENAALAD2 | |
| SCHEMBL7385019 | 0.91 | MME (0.64) | ACEMMEMMEL1NAALAD2 | |
| Water SCHEMBL10949495 | 0.90 | MME (0.62) | ACEMMEMMEL1NAALAD2 | |
| SCHEMBL9068701 | 0.89 | FOLH1 (0.52) | NAALAD2 | |
| SCHEMBL10944494 | 0.87 | ACE (0.50) | ACEMMEMMEL1 | |
| SCHEMBL7373739 | 0.86 | MME (0.48) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863467-A2 | COMBINATION OF ORGANIC COMPOUNDS | Novartis AG (US) | 2007-12-12 | — | — | EP | claimed |
| WO-2006086456-A2 | COMBINATION OF ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-08-17 | — | — | WO | claimed |