SCHEMBL560405

SCHEMBL560405

Fc1ccccc1CNC1=NCCN1

nearest known ligand 0.71

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.71
GAA P10253 1/20 0.71
APOBEC3A P31941 1/20 0.71
CTDSP1 Q9GZU7 1/20 0.71
APOBEC3G Q9HC16 1/20 0.71
SMN1; SMN2 Q16637 1/20 0.54
NLRP3 Q96P20 1/20 0.54
WDR5 P61964 15/20 0.50
NISCH Q9Y2I1 1/20 0.45
CXCR4 P61073 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13063071 0.88 LMNA (0.64) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
SCHEMBL10022889 0.85 LMNA (0.62) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
SCHEMBL561403 0.85 LMNA (0.62) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
SCHEMBL2154104 0.85 LMNA (0.97) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
SCHEMBL8146510 0.82 LMNA (0.58) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
SCHEMBL29315350 0.82 LMNA (0.55) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
SCHEMBL32665951 0.82 LMNA (0.55) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
Iodide SCHEMBL3168283 0.81 LMNA (0.60) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
SCHEMBL560777 0.81 LMNA (0.56) LMNAGAAAPOBEC3ACTDSP1APOBEC3G
SCHEMBL560664 0.81 LMNA (0.56) LMNAGAAAPOBEC3ACTDSP1APOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2303264-B1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS USING IMIDAZOLINE DERIVATIVES ALLERGAN INC (US) 2018-04-04 EP claimed
US-20150224080-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. 2015-08-13 US claimed
US-9034910-B2 Methods of treating alpha adrenergic mediated conditions ALLERGAN, INC. (US) 2015-05-19 US claimed
US-20120165380-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2012-06-28 US claimed
US-20120035235-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2012-02-09 US claimed
US-8071636-B2 Methods of treating alpha adrenergic mediated conditions ALLERGAN, INC. (US) 2011-12-06 US claimed
EP-2377534-A1 Methods of treating alpha adrenergic mediated conditions ALLERGAN, INC. (US) 2011-10-19 EP claimed
CN-102099032-A Methods of treating alpha adrenergic mediated conditions ALLERGAN INC 2011-06-15 CN claimed
EP-2303264-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS Allergan, Inc. (US) 2011-04-06 EP claimed
WO-2009152052-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-17 WO claimed
US-20090306161-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US claimed
US-20230062049-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. 2023-03-02 US disclosed
US-20230062049-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. 2023-03-02 US disclosed
US-20200330428-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN INC (US) 2020-10-22 US disclosed
US-20200330428-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN INC (US) 2020-10-22 US disclosed
US-20090306398-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20090306398-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20090306161-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20090306161-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20090306161-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306161-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2C, ADRA2A LMNA 1467/4885GAA 751/4885APOBEC3A 3206/4885
US-20230062049-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2A, ADRA2C LMNA 1464/4885GAA 733/4885APOBEC3A 3241/4885
US-20150224080-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2A, ADRA2C LMNA 1464/4885GAA 733/4885APOBEC3A 3241/4885
US-20090306398-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2C, ADRA2A LMNA 1467/4885GAA 751/4885APOBEC3A 3206/4885
US-20120035235-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2C, ADRA2A LMNA 1467/4885GAA 751/4885APOBEC3A 3206/4885
US-20200330428-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2A, ADRA2C LMNA 1464/4885GAA 733/4885APOBEC3A 3241/4885
US-20120165380-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2A, ADRA2C LMNA 1464/4885GAA 733/4885APOBEC3A 3241/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.