Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606963 | 0.81 | KMT2A (0.38) | KMT2ANPC1RAB9AATMCRHR1 | |
| SCHEMBL6834849 | 0.71 | GAA (0.47) | KMT2ANPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL5608032 | 0.68 | MAPT (0.48) | KMT2ANPC1RAB9AKDM4ETDP1 | |
| SCHEMBL773734 | 0.68 | LCK (0.51) | CRHR1L3MBTL1ALDH1A1HPGDPOLB | |
| SCHEMBL13584460 | 0.67 | NPC1 (0.45) | KMT2ANPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL6834770 | 0.67 | CHRNA7 (0.49) | KMT2AKDM4EALDH1A1MAPTPOLB | |
| SCHEMBL4719766 | 0.62 | CA1 (0.41) | KDM4EALDH1A1LPAR1LPAR5CYP2C19 | |
| SCHEMBL12687787 | 0.59 | MLYCD (0.44) | KMT2AKDM4EHPGDLMNALPAR1 | |
| SCHEMBL5607987 | 0.59 | ALDH1A1 (0.54) | KMT2ANPC1RAB9ACRHR1L3MBTL1 | |
| SCHEMBL13584825 | 0.59 | RAB9A (0.39) | KMT2ANPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | claimed |