Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5606238 | 0.78 | PGR (0.38) | NPC1KMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL5606522 | 0.77 | PLK1 (0.41) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL5607253 | 0.77 | MAPT (0.38) | LMNAKMT2AMEN1NPSR1ALDH1A1 | |
| SCHEMBL17844161 | 0.74 | FAAH (0.44) | NPC1LMNAKMT2AMEN1USP2 | |
| SCHEMBL5613996 | 0.74 | MAPT (0.46) | NPC1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL17844132 | 0.73 | FAAH (0.39) | KMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL17844174 | 0.73 | FAAH (0.40) | NPC1KMT2AMEN1NPSR1L3MBTL1 | |
| SCHEMBL3487021 | 0.73 | LMNA (0.41) | NPC1LMNAPKMKMT2AMEN1 | |
| SCHEMBL17844158 | 0.72 | GAA (0.43) | NPC1KMT2AMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL17844070 | 0.72 | FAAH (0.40) | NPC1KMT2AMEN1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | claimed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | claimed |