Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TPO | P07202 | 1/20 | 0.36 |
| ▸ | EPX | P11678 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608564 | 0.86 | MPO (0.39) | MPOALDH1A1MAOBDAO | |
| SCHEMBL5608541 | 0.81 | MAPT (0.40) | MPOALDH1A1HPGDALPLMAOB | |
| SCHEMBL5608922 | 0.79 | MAOA (0.40) | CYP3A4ALDH1A1HPGDMAOB | |
| SCHEMBL5608921 | 0.75 | AR (0.38) | — | |
| SCHEMBL5618439 | 0.69 | MAPT (0.40) | MPOCYP3A4ALDH1A1HPGDALPL | |
| SCHEMBL5608450 | 0.64 | ALDH1A1 (0.39) | CYP3A4PARP1ALDH1A1HPGD | |
| SCHEMBL1514183 | 0.62 | HTR2A (0.48) | CYP3A4BCL2BCL2L1ALDH1A1MAOB | |
| SCHEMBL6839208 | 0.62 | HTR2A (0.48) | CYP3A4BCL2BCL2L1ALDH1A1MAOB | |
| SCHEMBL11495775 | 0.62 | AOC3 (0.43) | DHFRMPOCYP3A4TPOEPX | |
| SCHEMBL542553 | 0.60 | HTR2A (0.56) | DHFRCYP3A4BCL2BCL2L1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |