Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608587 | 0.88 | SNCA (0.39) | SNCACYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL5608967 | 0.88 | SNCA (0.39) | SNCAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5608745 | 0.83 | SNCA (0.40) | MAOAMAOBSNCACYP3A4ALDH1A1 | |
| SCHEMBL5608228 | 0.79 | PNP (0.36) | MAOBCYP3A4ALDH1A1HPGD | |
| SCHEMBL5608905 | 0.79 | ALDH1A1 (0.46) | MAOAMAOBHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL5608461 | 0.76 | GABRA1 (0.34) | MAOAMAOBSNCAALDH1A1L3MBTL1 | |
| SCHEMBL5608778 | 0.76 | ALOX15 (0.41) | MAOAMAOBSNCAHSD17B10CYP1A2 | |
| SCHEMBL5608736 | 0.72 | TSHR (0.40) | CYP3A4ALDH1A1MAPK1 | |
| SCHEMBL40607 | 0.67 | ALDH1A1 (0.60) | HSD17B10ALDH1A1ARNPC1RAB9A | |
| SCHEMBL5248985 | 0.67 | CYP1A2 (0.59) | CYP1A2CYP3A4CYP2C19ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |