Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PGK1 | P00558 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608587 | 0.76 | SNCA (0.39) | TSHRMAPK1ALDH1A1CYP3A4LMNA | |
| SCHEMBL8199562 | 0.74 | MAPK1 (0.46) | TSHRMAPK1ALDH1A1CYP3A4VCAM1 | |
| SCHEMBL5608778 | 0.74 | ALOX15 (0.41) | MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL8872707 | 0.72 | CES1 (0.62) | TSHRMAPK1AKR1B1ALDH1A1CYP3A4 | |
| SCHEMBL5608922 | 0.72 | MAOA (0.40) | MAPK1ALDH1A1CYP3A4 | |
| SCHEMBL29835178 | 0.70 | CYP3A4 (0.50) | TSHRMAPK1AKR1B1ALDH1A1CYP3A4 | |
| SCHEMBL438752 | 0.70 | CYP3A4 (0.50) | TSHRMAPK1AKR1B1ALDH1A1CYP3A4 | |
| SCHEMBL786237 | 0.70 | CYP3A4 (0.50) | TSHRMAPK1AKR1B1ALDH1A1CYP3A4 | |
| SCHEMBL5608967 | 0.70 | SNCA (0.39) | ALDH1A1LMNA | |
| SCHEMBL6820729 | 0.70 | PTPRC (0.50) | ALDH1A1CYP3A4CA12CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |