Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PSD | A5PKW4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608967 | 0.88 | SNCA (0.39) | SNCANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL5608922 | 0.88 | MAOA (0.40) | SNCACYP1A2CYP2C19HPGDCYP3A4 | |
| SCHEMBL5608745 | 0.86 | SNCA (0.40) | SNCACYP3A4MAPTPOLBTDP1 | |
| SCHEMBL5608564 | 0.80 | MPO (0.39) | NPC1LMNARAB9AMAPTMEN1 | |
| SCHEMBL5608736 | 0.76 | TSHR (0.40) | CYP3A4LMNATSHRMAPK1ALDH1A1 | |
| SCHEMBL5608461 | 0.74 | GABRA1 (0.34) | SNCAL3MBTL1MAPTMEN1KMT2A | |
| SCHEMBL5608778 | 0.74 | ALOX15 (0.41) | SNCACYP1A2CYP2C19CYP3A4MAPK1 | |
| SCHEMBL5608905 | 0.69 | ALDH1A1 (0.46) | CYP1A2CYP2C19HPGDCYP3A4NPC1 | |
| SCHEMBL2657113 | 0.68 | SNCA (0.43) | SNCACYP1A2CYP2C19HPGDCYP3A4 | |
| SCHEMBL5618439 | 0.67 | MAPT (0.40) | HPGDCYP3A4LMNAMAPTDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | disclosed |