Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CPA3 | P15088 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238111 | 0.76 | EPHX1 (0.48) | ACEEPHX1ANPEPCPA1SLC6A2 | |
| SCHEMBL16034061 | 0.74 | EPHX1 (0.46) | ACEEPHX1ANPEPCPA1SLC6A2 | |
| SCHEMBL5609931 | 0.73 | EPHX1 (0.50) | EPHX1ANPEPSLC6A2TAAR1SLC6A4 | |
| SCHEMBL10693279 | 0.73 | EPHX1 (0.44) | ACEEPHX1ANPEPCPA1SLC6A2 | |
| SCHEMBL5609280 | 0.73 | CPA1 (0.46) | ACEEPHX1ANPEPCPA1SLC6A2 | |
| SCHEMBL838906 | 0.73 | MEN1 (0.46) | ACEEPHX1CPA1SLC6A2TAAR1 | |
| SCHEMBL7256073 | 0.73 | EPHX1 (0.44) | ACEEPHX1ANPEPCPA1SLC6A2 | |
| SCHEMBL2059538 | 0.73 | EPHX1 (0.44) | ACEEPHX1ANPEPCPA1SLC6A2 | |
| SCHEMBL6380241 | 0.73 | EPHX1 (0.56) | EPHX1ANPEPSLC6A2TAAR1SLC6A4 | |
| SCHEMBL638408 | 0.73 | EPHX1 (0.56) | EPHX1ANPEPSLC6A2TAAR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199139-B2 | Medicinal compositions containing diuretic and insulin resistance-improving agent | SANKYO COMPANY, LIMITED (JP) | 2007-04-03 | — | — | US | disclosed |
| EP-1354602-B1 | MEDICINAL COMPOSITIONS CONTAINING DIURETIC AND INSULIN RESISTANCE-IMPROVING AGENT | SANKYO CO (JP) | 2006-10-04 | — | — | EP | disclosed |
| EP-1695716-A2 | Medicinal compositions containing diuretics and insulin sensitizers | Sankyo Company, Limited (JP) | 2006-08-30 | — | — | EP | disclosed |
| US-20050288339-A1 | Medicinal compositions containing diuretic and insulin resistance-improving agent | SANKYO COMPANY, LIMITED (JP) | 2005-12-29 | — | — | US | disclosed |
| US-20040053974-A1 | Medicinal compositions containing diuretic and insulin resistance-improving agent | SANKYO COMPANY, LIMITED (JP) | 2004-03-18 | — | — | US | disclosed |
| US-20040002512-A1 | Alpha-substituted carboxylic acid derivatives | SANKYO COMPANY, LIMITED (JP) | 2004-01-01 | — | — | US | disclosed |
| EP-1354602-A1 | MEDICINAL COMPOSITIONS CONTAINING DIURETIC AND INSULIN RESISTANCE-IMPROVING AGENT | Sankyo Company, Limited (JP) | 2003-10-22 | — | — | EP | disclosed |
| US-6596751-B2 | An insulin resistance improving agent, hypoglycemic agent, immunoregulatory agent, aldose reductase inhibitor, 5-lipoxygenase inhibitor, peroxidized lipid production suppressor, PPAR. activator, leukotriene antagonist, adipose | SANKYO COMPANY LIMITED (JP) | 2003-07-22 | — | — | US | disclosed |
| US-20030069294-A1 | Alpha-substituted carboxylic acid derivatives | SANKYO COMPANY, LIMITED (JP) | 2003-04-10 | — | — | US | disclosed |
| EP-1167357-A1 | ALPHA-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES | Sankyo Company, Limited (JP) | 2002-01-02 | — | — | EP | disclosed |
| US-6191297-B1 | HYDROSILATION OF FUNCTIONALLIZED ALLYL COMPOUNDS, E.G. ALLYL CHLORIDE, BY HYDROGEN SILANES, E.G. DICHLOROMETHYLSILANE, USING A CATALYST OF A COMPLEX OF PLATINUM AND ONE OR MORE SULFUR-CONTAINING LIGANDS; EFFICIENCY | DEGUSSA-HULS AG (DE) | 2001-02-20 | — | — | US | disclosed |
| EP-0645355-B1 | Method for the preparation of trifluoroethyl sulphur compounds from thiolates and 1-chloro-2,2,2-trifluoroethane | SOLVAY (BE) | 2000-03-22 | — | — | EP | disclosed |
| CN-1241570-A | New process for preparation of organosilanes functionalised in the 3-position | DEGUSSA (DE) | 2000-01-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002512-A1 | Alpha-substituted carboxylic acid derivatives | SLC5A1, SLC2A1, GPR119 | ACE 2201/4885EPHX1 2395/4885ANPEP 3250/4885 |
| US-20030069294-A1 | Alpha-substituted carboxylic acid derivatives | SLC5A1, SLC2A1, GPR119 | ACE 2201/4885EPHX1 2395/4885ANPEP 3250/4885 |
| US-20040053974-A1 | Medicinal compositions containing diuretic and insulin resistance-improving agent | GPR119, INSR, IRS1 | ACE 170/4885EPHX1 2426/4885ANPEP 1993/4885 |
| US-20050288339-A1 | Medicinal compositions containing diuretic and insulin resistance-improving agent | GPR119, INSR, IRS1 | ACE 170/4885EPHX1 2426/4885ANPEP 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.