Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197897 | 0.82 | ALDH1A1 (0.38) | ALDH1A1HPGDGAAXDHMAPT | |
| SCHEMBL6166807 | 0.79 | BRD4 (0.42) | GAATSHR | |
| SCHEMBL29378909 | 0.77 | CNR2 (0.46) | ALDH1A1MAPTKDM4EL3MBTL1CNR2 | |
| SCHEMBL11246560 | 0.77 | GAA (0.47) | METAP2ALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL20849 | 0.77 | GAA (0.47) | METAP2ALDH1A1HPGDGAAHSD17B10 | |
| Lithium SCHEMBL9356286 | 0.76 | GAA (0.46) | METAP2ALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL35210234 | 0.76 | GAA (0.46) | METAP2ALDH1A1HPGDGAAHSD17B10 | |
| Ammonia Solution, Strong SCHEMBL2774227 | 0.76 | GAA (0.46) | METAP2ALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL11053122 | 0.76 | GAA (0.46) | METAP2ALDH1A1HPGDGAAHSD17B10 | |
| Hydrochloric Acid SCHEMBL5705213 | 0.76 | GAA (0.46) | METAP2ALDH1A1HPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004116-A1 | 1H-1,2,3-triazol-4-yl derivatives; antiangiogenesis agents | SMITHKLINE BEECHAM CORPORATION | 2005-01-06 | — | — | US | claimed |
| US-20030220371-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2003-11-27 | — | — | US | claimed |
| EP-1274424-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | claimed |
| EP-1274424-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-15 | — | — | EP | claimed |
| WO-2001078723-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-25 | — | — | WO | claimed |
| EP-3344612-B1 | SPINOSYN DERIVATIVES AS INSECTICIDES | AGRIMETIS LLC (US) | 2020-06-17 | — | — | EP | disclosed |
| US-10570166-B2 | Spinosyn derivatives as insecticides | AGRIMETIS, LLC (US) | 2020-02-25 | — | — | US | disclosed |
| EP-3189050-B1 | ANTIVIRAL AGENTS AND USES THEREOF | UNIV GRIFFITH (AU) | 2020-02-05 | — | — | EP | disclosed |
| CN-106146417-B | A method of 4- aryl-NH-1,2,3- triazole is prepared using aldehyde sodium bisulfite adduct | 海南师范大学 | 2018-12-04 | — | — | CN | disclosed |
| US-20180251487-A1 | SPINOSYN DERIVATIVES AS INSECTICIDES | AGRIMETIS, LLC (US) | 2018-09-06 | — | — | US | disclosed |
| EP-3344612-A1 | SPINOSYN DERIVATIVES AS INSECTICIDES | Agrimetis, LLC (US) | 2018-07-11 | — | — | EP | disclosed |
| CN-107108584-A | Antivirotic and its application | 格里菲斯大学 | 2017-08-29 | — | — | CN | disclosed |
| US-20070077641-A1 | Methionine aminopeptidase and methods of use | PALMER LESLIE | 2007-04-05 | — | — | US | disclosed |
| EP-1624849-A2 | METHIONINE AMINOPEPTIDASE AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-15 | — | — | EP | disclosed |
| WO-2005016237-A2 | METHIONINE AMINOPEPTIDASE AND METHODS OF USE | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| US-20050004116-A1 | 1H-1,2,3-triazol-4-yl derivatives; antiangiogenesis agents | SMITHKLINE BEECHAM CORPORATION | 2005-01-06 | — | — | US | disclosed |
| US-20030220371-A1 | Compounds and methods | SMITHKLINE BEECHAM CORPORATION | 2003-11-27 | — | — | US | disclosed |
| EP-1274424-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2003-09-17 | — | — | EP | disclosed |
| EP-1274424-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001078723-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570166-B2 | Spinosyn derivatives as insecticides | SPIN3, ACHE, SPIN4 | METAP2 1124/4885ALDH1A1 3854/4885HPGD 2670/4885 |
| US-20050004116-A1 | 1H-1,2,3-triazol-4-yl derivatives; antiangiogenesis agents | METAP1, METAP2, DNPEP | METAP2 2/4885ALDH1A1 1107/4885HPGD 2469/4885 |
| US-20030220371-A1 | Compounds and methods | METAP2, METAP1, DNPEP | METAP2 1/4885ALDH1A1 1579/4885HPGD 1838/4885 |
| US-20180251487-A1 | SPINOSYN DERIVATIVES AS INSECTICIDES | SPIN3, ACHE, SPIN4 | METAP2 1124/4885ALDH1A1 3854/4885HPGD 2670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.