Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10911466 | 0.88 | NT5E (0.42) | NT5EPRMT5WDR77LMNAMTOR | |
| SCHEMBL1740045 | 0.86 | ALB (0.45) | NT5EPRMT5WDR77LMNAMTOR | |
| SCHEMBL2577234 | 0.78 | LMNA (0.62) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL770117 | 0.78 | LMNA (0.62) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL770116 | 0.78 | LMNA (0.62) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL6312068 | 0.78 | NT5E (0.65) | NT5ELMNAMTORTHRBMDM2 | |
| SCHEMBL223209 | 0.78 | NT5E (0.65) | NT5ELMNAMTORTHRBMDM2 | |
| SCHEMBL4428196 | 0.77 | LMNA (0.43) | NT5EPRMT5WDR77LMNAMTOR | |
| SCHEMBL360322 | 0.72 | PDE2A (0.55) | NT5ELMNAMTORTHRBMDM2 | |
| SCHEMBL6716522 | 0.72 | PDE2A (0.55) | NT5ELMNAMTORTHRBMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007106450-A2 | DIKETO ACIDS WITH NUCLEOBASE SCAFFOLDS: ANTI-HIV REPLICATION INHIBITORS TARGETED AT HIV INTEGRASE IN COMBINATION THERAPY | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2007-09-20 | — | — | WO | claimed |