Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9235448 | 0.88 | SIGMAR1 (0.50) | SIGMAR1MPO | |
| SCHEMBL2952166 | 0.86 | SIGMAR1 (0.71) | SIGMAR1 | |
| SCHEMBL29385038 | 0.83 | HTR6 (0.46) | SIGMAR1PTPN1CNR1 | |
| SCHEMBL16913235 | 0.83 | HTR6 (0.46) | SIGMAR1PTPN1CNR1 | |
| SCHEMBL14290594 | 0.81 | SIGMAR1 (0.55) | SIGMAR1 | |
| SCHEMBL11543020 | 0.81 | SIGMAR1 (0.51) | SIGMAR1CNR1 | |
| SCHEMBL11503302 | 0.80 | MPO (0.57) | SIGMAR1HTTMPO | |
| SCHEMBL30151590 | 0.80 | PTPN1 (0.43) | SIGMAR1PTPN1CNR1 | |
| SCHEMBL7406702 | 0.77 | SIGMAR1 (0.50) | SIGMAR1MPO | |
| SCHEMBL20430497 | 0.77 | HTR6 (0.47) | SIGMAR1PTPN1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608212-B1 | Palladium catalyzed coupling of a vinylphosphate and aryl-metal halide; preparation of such as 1-(4-(2-(pyrrolidin-n-yl)-ethoxy)phenyl)-6-methoxy-3,4-dihydronaphthalene | PFIZER, INC. | 2003-08-19 | — | — | US | claimed |
| EP-1754709-A1 | Process for preparing vinylphosphates | DSM IP Assets B.V. (NL) | 2007-02-21 | — | — | EP | disclosed |
| EP-1509484-A2 | PROCESS FOR PREPARING VINYLAROMATIC COMPOUNDS | DSM IP Assets B.V. (NL) | 2005-03-02 | — | — | EP | disclosed |
| WO-2003102202-A2 | PROCESS FOR PREPARING VINYLAROMATIC COMPOUNDS | DSM IP ASSETS B.V. (NL) | 2003-12-11 | — | — | WO | disclosed |
| US-6608212-B1 | Palladium catalyzed coupling of a vinylphosphate and aryl-metal halide; preparation of such as 1-(4-(2-(pyrrolidin-n-yl)-ethoxy)phenyl)-6-methoxy-3,4-dihydronaphthalene | PFIZER, INC. | 2003-08-19 | — | — | US | disclosed |