Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.84 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.84 |
| ▸ | LMNA | P02545 | 5/20 | 0.84 |
| ▸ | HTT | P42858 | 2/20 | 0.84 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | CASP3 | P42574 | 2/20 | 0.69 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.69 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.69 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | MIF | P14174 | 6/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.61 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618362 | 1.00 | MAPT (0.84) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL14454079 | 0.86 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL5573384 | 0.86 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL5573382 | 0.86 | MAPT (0.63) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL30967992 | 0.82 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL8547900 | 0.82 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL8547897 | 0.82 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL25609318 | 0.82 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL14800018 | 0.80 | MAPT (0.79) | MAPTSMN1; SMN2ALDH1A1LMNAHTT | |
| SCHEMBL6954573 | 0.79 | MAPT (0.81) | MAPTSMN1; SMN2ALDH1A1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235674-B2 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2007-06-26 | — | — | US | disclosed |
| US-7015328-B2 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2006-03-21 | — | — | US | disclosed |
| US-20050090526-A1 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2005-04-28 | — | — | US | disclosed |
| EP-1392283-A4 | SUBSTITUTED COUMARINS AND QUINOLINES AS CASPASE ACTIVATORS | CYTOVIA INC (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1392283-A1 | SUBSTITUTED COUMARINS AND QUINOLINES AS CASPASES ACTIVATORS | Cytovia, Inc. (US) | 2004-03-03 | — | — | EP | disclosed |
| US-20030114485-A1 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2003-06-19 | — | — | US | disclosed |
| WO-2002092076-A1 | SUBSTITUTED COUMARINS AND QUINOLINES AS CASPASES ACTIVATORS | CYTOVIA, INC. (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030114485-A1 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP7, CASP1, CASP5 | MAPT 4446/4885SMN1; SMN2 4828/4885ALDH1A1 1275/4885 |
| US-20050090526-A1 | Substituted coumarins and quinolines and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP7, CASP5, CASP14 | MAPT 4420/4885SMN1; SMN2 4847/4885ALDH1A1 1656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.