Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 5/20 | 0.51 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268116 | 0.95 | EHMT2 (0.57) | EHMT2EHMT1TLR7TLR9 | |
| SCHEMBL6266570 | 0.92 | EGFR (0.46) | EHMT2EHMT1EGFRKDRFGFR1 | |
| SCHEMBL3727488 | 0.87 | EGFR (0.49) | EHMT2EHMT1TLR7TLR9EGFR | |
| SCHEMBL6266172 | 0.83 | EGFR (0.46) | EGFRKDRFGFR1FLT1 | |
| SCHEMBL6269488 | 0.82 | EGFR (0.42) | EHMT2EHMT1TLR7TLR9EGFR | |
| SCHEMBL6266311 | 0.81 | EGFR (0.44) | EHMT2EHMT1TLR7TLR9EGFR | |
| SCHEMBL8444662 | 0.81 | EPHA2 (0.44) | EHMT2EHMT1TLR7TLR9KDR | |
| SCHEMBL8436900 | 0.80 | EPHA2 (0.42) | EHMT2EHMT1TLR7TLR9KDR | |
| SCHEMBL8438071 | 0.80 | KDR (0.38) | EHMT2EHMT1TLR7TLR9EGFR | |
| SCHEMBL8444635 | 0.75 | EPHA2 (0.36) | KDRFLT1EPHA2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007013950-A9 | COMBINATION THERAPY OF HER EXPRESSING TUMORS | GENENTECH INC (US) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007013950-A2 | COMBINATION THERAPY OF HER EXPRESSING TUMORS | GENENTECH, INC. (US) | 2007-02-01 | — | — | WO | disclosed |