Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.34 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8436900 | 0.96 | EPHA2 (0.42) | EPHA2KDREPHB4TLR7TLR9 | |
| SCHEMBL8438071 | 0.92 | KDR (0.38) | EPHA2KDREPHB4TLR7TLR9 | |
| SCHEMBL28962458 | 0.81 | EPHA2 (0.45) | EPHA2KDREPHB4CHEK1CHEK2 | |
| SCHEMBL5618725 | 0.81 | EHMT2 (0.51) | EPHA2KDREPHB4TLR7TLR9 | |
| SCHEMBL6266570 | 0.80 | EGFR (0.46) | EPHA2KDREPHB4EHMT2EHMT1 | |
| SCHEMBL6269488 | 0.80 | EGFR (0.42) | TLR7TLR9PDGFRBPDGFRAKDM4E | |
| SCHEMBL6268116 | 0.80 | EHMT2 (0.57) | TLR7TLR9EHMT2EHMT1 | |
| SCHEMBL3727488 | 0.80 | EGFR (0.49) | KDREPHB4TLR7TLR9EHMT2 | |
| SCHEMBL6266311 | 0.79 | EGFR (0.44) | KDRTLR7TLR9PDGFRBPDGFRA | |
| SCHEMBL8444635 | 0.79 | EPHA2 (0.36) | EPHA2KDREPHB4PDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892799-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038994-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-10-23 | — | — | WO | disclosed |