Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.53 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5333494 | 0.89 | ALDH1A1 (0.58) | ESR1ALDH1A1USP2KEAP1PGR | |
| SCHEMBL5622597 | 0.85 | ALDH1A1 (0.53) | ALDH1A1USP2KEAP1PGRNFE2L2 | |
| SCHEMBL5623827 | 0.83 | KEAP1 (0.51) | ALDH1A1USP2KEAP1PGRNFE2L2 | |
| SCHEMBL5622125 | 0.83 | PSEN1 (0.60) | ALDH1A1USP2KEAP1PGRNFE2L2 | |
| SCHEMBL27927813 | 0.79 | BMP1 (0.60) | ALDH1A1GAAHPGDMDM4MDM2 | |
| SCHEMBL2119628 | 0.79 | PSEN1 (0.52) | ESR1ALDH1A1KEAP1PGRNR3C1 | |
| SCHEMBL5622356 | 0.78 | PGR (0.79) | ALDH1A1KEAP1PGRNFE2L2PKM | |
| SCHEMBL5622395 | 0.78 | ESR1 (0.83) | ESR1ALDH1A1LMNAL3MBTL1HSD11B1 | |
| SCHEMBL5623334 | 0.77 | KEAP1 (0.62) | ALDH1A1KEAP1PGRNFE2L2LMNA | |
| SCHEMBL2118315 | 0.77 | PSEN1 (0.57) | ALDH1A1PGRGAALMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070021495-A1 | SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021495-A1 | SULFONAMIDES AS SELECTIVE ESTROGEN RECEPTOR | ESR1, ESR2, GPER1 | ESR1 1/4885ALDH1A1 826/4885USP2 3000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.