Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | USP2 | O75604 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL562770 | 0.87 | ALDH1A1 (0.68) | ALDH1A1NPSR1MEN1KMT2AUSP2 | |
| SCHEMBL562822 | 0.80 | MYB (0.61) | ALDH1A1NPSR1MEN1KMT2AUSP2 | |
| SCHEMBL29460082 | 0.80 | MYB (0.61) | ALDH1A1NPSR1MEN1KMT2AUSP2 | |
| SCHEMBL6706771 | 0.77 | GAA (0.73) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL6705972 | 0.76 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL3129599 | 0.74 | ALDH1A1 (0.72) | ALDH1A1NPSR1MEN1KMT2AUSP2 | |
| SCHEMBL10046494 | 0.73 | GAA (0.56) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL28664531 | 0.70 | ALDH1A1 (0.78) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL14904060 | 0.69 | GAA (0.51) | ALDH1A1MEN1KMT2AUSP2MAPT | |
| SCHEMBL5548111 | 0.69 | ALDH1A1 (0.66) | ALDH1A1NPSR1MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130345420-A9 | SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) | BUNCH LENNART (DK) | 2013-12-26 | — | — | US | disclosed |
| US-20120035361-A1 | SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) | BUNCH LENNART (DK) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035361-A1 | SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) | SLC1A1, SLC1A2, SLC1A3 | ALDH1A1 520/4885NPSR1 822/4885MEN1 3547/4885 |
| US-20130345420-A9 | SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) | SLC1A1, SLC1A2, SLC1A3 | ALDH1A1 520/4885NPSR1 822/4885MEN1 3547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.