Sugi Predict

Sugi Predict / Compounds / SCHEMBL562822

SCHEMBL562822

SCHEMBL562822

COc1ccc(C2C(C#N)=C(N)OC3=C2C(=O)CC(c2cccc4ccccc24)C3)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MYB P10242 7/20 0.61
▸ ALDH1A1 P00352 7/20 0.57
▸ MAPT P10636 4/20 0.52
▸ HTT P42858 2/20 0.52
▸ MEN1 O00255 4/20 0.49
▸ KMT2A Q03164 4/20 0.49
▸ NPSR1 Q6W5P4 2/20 0.49
▸ CYP1A2 P05177 1/20 0.49
▸ CYP3A4 P08684 1/20 0.49
▸ CYP2C9 P11712 1/20 0.49
▸ CYP2C19 P33261 1/20 0.49
▸ RECQL P46063 1/20 0.49
▸ GRIA3 P42263 1/20 0.49
▸ GRIA4 P48058 1/20 0.49
▸ USP2 O75604 2/20 0.48
▸ TP53 P04637 1/20 0.47
▸ TSHR P16473 1/20 0.46
▸ GAA P10253 1/20 0.46
▸ POLB P06746 1/20 0.46
▸ LMNA P02545 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29460082 1.00 MYB (0.61) MYBALDH1A1MAPTHTTMEN1
SCHEMBL562770 0.86 ALDH1A1 (0.68) MYBALDH1A1MAPTHTTMEN1
SCHEMBL562771 0.83 ALDH1A1 (0.50) MYBALDH1A1MAPTHTTMEN1
SCHEMBL562289 0.80 ALDH1A1 (0.61) MYBALDH1A1MAPTHTTMEN1
SCHEMBL6706771 0.74 GAA (0.73) ALDH1A1MAPTMEN1KMT2ACYP1A2
SCHEMBL3129599 0.73 ALDH1A1 (0.72) ALDH1A1MAPTHTTMEN1KMT2A
SCHEMBL6705972 0.73 ALDH1A1 (1.00) ALDH1A1MAPTMEN1KMT2AGRIA3
SCHEMBL27972027 0.71 MYB (0.84) MYB
SCHEMBL3123679 0.68 ALDH1A1 (0.70) ALDH1A1MAPTHTTMEN1KMT2A
SCHEMBL31237961 0.67 MYB (0.80) MYBMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230136218-A1 METHODS AND COMPOSITIONS FOR TREATING ACUTE MYELOID LEUKEMIA PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-05-04 — — US claimed
US-12162891-B2 Glutamate transporter activators and methods using same DREXEL UNIVERSITY (US) 2024-12-10 — — US disclosed
US-20240052418-A1 METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2024-02-15 — — US disclosed
US-11814681-B2 Method for predicting a subjects response to SLC modulator therapy THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2023-11-14 — — US disclosed
US-20230136218-A1 METHODS AND COMPOSITIONS FOR TREATING ACUTE MYELOID LEUKEMIA PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-05-04 — — US disclosed
US-20230054895-A1 METHODS FOR INDUCING BIOSTASIS IN A CELL, TISSUE OR ORGAN PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-02-23 — — US disclosed
US-20220402938-A1 GLUTAMATE TRANSPORTER ACTIVATORS AND METHODS USING SAME UNIV DREXEL (US) 2022-12-22 — — US disclosed
US-20220267308-A1 Modulators of Excitatory Amino Acid Transporters and Methods Using Same DREXEL UNIVERSITY 2022-08-25 — — US disclosed
US-11377452-B2 Glutamate transporter activators and methods using same DREXEL UNIVERSITY (US) 2022-07-05 — — US disclosed
US-20210254158-A1 METHOD FOR PREDICTING A SUBJECTS RESPONSE TO SLC MODULATOR THERAPY RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC. 2021-08-19 — — US disclosed
WO-2019046303-A1 A METHOD FOR PREDICTING A SUBJECT'S RESPONSE TO SLC MODULATOR THERAPY THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-03-07 — — WO disclosed
WO-2018150260-A1 METHOD FOR THE IDENTIFICATION OF MUTATED PROTEINS HAVING MODIFIED THERMAL STABILITY INSTITUT PASTEUR (FR) 2018-08-23 — — WO disclosed
US-20130345420-A9 SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) BUNCH LENNART (DK) 2013-12-26 — — US disclosed
US-20120258998-A1 Fusion genes in gastrointestinal cancer NATIONAL UNIVERSITY OF SINGAPORE (SG) 2012-10-11 — — US disclosed
US-20120035361-A1 SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) BUNCH LENNART (DK) 2012-02-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120035361-A1 SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) SLC1A1, SLC1A2, SLC1A3 MYB 4689/4885ALDH1A1 520/4885MAPT 298/4885
US-20220402938-A1 GLUTAMATE TRANSPORTER ACTIVATORS AND METHODS USING SAME SLC1A2, SLC1A1, SLC1A3 MYB 3277/4885ALDH1A1 1098/4885MAPT 365/4885
US-12162891-B2 Glutamate transporter activators and methods using same SLC1A2, SLC1A1, SLC1A3 MYB 3277/4885ALDH1A1 1098/4885MAPT 365/4885
US-20220267308-A1 Modulators of Excitatory Amino Acid Transporters and Methods Using Same SLC1A2, SLC1A1, SLC1A3 MYB 3955/4885ALDH1A1 1178/4885MAPT 730/4885
US-11377452-B2 Glutamate transporter activators and methods using same SLC1A2, SLC1A1, SLC1A3 MYB 3277/4885ALDH1A1 1098/4885MAPT 365/4885
US-20230054895-A1 METHODS FOR INDUCING BIOSTASIS IN A CELL, TISSUE OR ORGAN OPRL1, OPRK1, OPRD1 MYB 3214/4885ALDH1A1 1068/4885MAPT 2778/4885
US-20130345420-A9 SELECTIVE INHIBITORS OF EXCITATORY AMINO ACID TRANSPORTER SUBTYPE 1 (EAAT1/GLAST) SLC1A1, SLC1A2, SLC1A3 MYB 4689/4885ALDH1A1 520/4885MAPT 298/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.