Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | HPGD | P15428 | 2/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.98 |
| ▸ | DRD1 | P21728 | 5/20 | 0.73 |
| ▸ | HTR2C | P28335 | 3/20 | 0.73 |
| ▸ | PTPRCAP | Q14761 | 1/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23949488 | 1.00 | DRD2 (1.00) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29039792 | 0.90 | DRD2 (0.81) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9976807 | 0.86 | DRD1 (0.76) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| Laurotetanine SCHEMBL905065 | 0.85 | DRD2 (0.74) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| Laurotetanine SCHEMBL905125 | 0.85 | DRD2 (0.74) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| Laurotetanine SCHEMBL31300083 | 0.85 | DRD2 (0.74) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| Nornuciferine SCHEMBL29787894 | 0.85 | HTR2C (1.00) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| Nornuciferine SCHEMBL29501026 | 0.85 | HTR2C (1.00) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30298991 | 0.83 | DRD2 (0.71) | DRD2KDM4EALDH1A1HPGDHSD17B10 | |
| Norcorydine SCHEMBL31504460 | 0.81 | DRD2 (0.69) | DRD2KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105367494-A | Sinomenine derivative and preparing method thereof | RUIAN PULUO BIOLOGICAL SCIENCE & TECH CO LTD | 2016-03-02 | — | — | CN | claimed |
| CN-103232467-B | A kind of Sinomenine structure-modified compound and preparation method thereof | ZHENGQING PHARMACEUTICAL GROUP CORP., LTD., HUNAN PROV. (CN) | 2015-11-18 | — | — | CN | claimed |
| CN-104672142-A | Preparation and medical purpose of dual structure sinomenine derivative | UNIV JIANGSU | 2015-06-03 | — | — | CN | claimed |
| CN-104649854-A | Cheap and efficient preparation method of aryl halides | UNIV BEIJING | 2015-05-27 | — | — | CN | claimed |
| CN-104497167-A | Hyaluronic acid derivative and therapeutic thereof | SHANDONG PHARMACEUTICAL ACADEMY | 2015-04-08 | — | — | CN | claimed |
| CN-104311489-A | Green environmentally-friendly industrial sinomenine extraction and separation method | WANG XIAOLING | 2015-01-28 | — | — | CN | claimed |
| CN-104193680-A | Method for extracting sinomenine hydrochloride from caulis sinomenii | NANJING BIAOKE BIO TECHNOLOGY CO LTD | 2014-12-10 | — | — | CN | claimed |
| CN-102304087-B | Cucoline derivative as well as salts, preparation method and application thereof | UNIV PLA 2ND MILITARY MEDICAL | 2014-08-13 | — | — | CN | claimed |
| CN-102260212-B | Sinomenine derivatives, and preparation method and application thereof | NANJING UNIVERSITY OF TECHNOLOGY | 2014-05-21 | — | — | CN | claimed |
| CN-103232467-A | Kukoline structurally-reconstructed compound and preparation method thereof | HUNAN ZHENGQIN PHARMACEUTICAL GROUP CO LTD | 2013-08-07 | — | — | CN | claimed |
| CN-1298720-C | Sinomenine derivative with C cycle connected to penetabasic heterocycle and synthesizing method | SHANGHAI INST ORGANIC CHEM (CN) | 2007-02-07 | — | — | CN | claimed |
| CN-1785976-A | N-alkyl diversine and its preparation method | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2006-06-14 | — | — | CN | claimed |
| CN-1687065-A | Derivative of sinomenine with pyrazinc cyclc being connected to C cycle, synthetic method and application | SHANGHAI INST ORGANIC CHEM (CN) | 2005-10-26 | — | — | CN | claimed |
| CN-1687070-A | Sinomenine derivative with C cycle connected to penetabasic heterocycle and synthesizing method | SHANGHAI INST ORGANIC CHEM (CN) | 2005-10-26 | — | — | CN | claimed |
| CN-1174983-C | Method for purifying diversine | 上海中医药大学 | 2004-11-10 | — | — | CN | claimed |
| CN-1405167-A | Method for purifying diversine | SHANGHAI TRADITIONAL CHINESE M (CN) | 2003-03-26 | — | — | CN | claimed |
| CN-1053892-C | Preparation method of diversine | TIANCHENG MEDICINE BIOLOG ENGR (CN) | 2000-06-28 | — | — | CN | claimed |
| CN-1153171-A | Anticancer preparation | XI AN MEDICAL UNIV (CN) | 1997-07-02 | — | — | CN | claimed |
| CN-1125724-A | Preparation method of diversine | TIANCHENG MEDICINE BIOLOG ENGI (CN) | 1996-07-03 | — | — | CN | claimed |
| CN-1113270-A | Preparation for organic inclusion compound large crystal with second-order nonlinear optical effect | UNIV LIAONING NORMAL (CN) | 1995-12-13 | — | — | CN | claimed |