Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 4/20 | 0.76 |
| ▸ | HTR2C | P28335 | 4/20 | 0.76 |
| ▸ | PTPRCAP | Q14761 | 2/20 | 0.76 |
| ▸ | DRD2 | P14416 | 4/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | TDP2 | O95551 | 2/20 | 0.58 |
| ▸ | CASP3 | P42574 | 2/20 | 0.58 |
| ▸ | RAD52 | P43351 | 2/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.58 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Laurotetanine SCHEMBL905125 | 0.92 | DRD2 (0.74) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| Laurotetanine SCHEMBL905065 | 0.92 | DRD2 (0.74) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| Laurotetanine SCHEMBL31300083 | 0.92 | DRD2 (0.74) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| SCHEMBL14259791 | 0.90 | DRD1 (0.71) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| SCHEMBL6689417 | 0.87 | DRD1 (0.65) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| Nornuciferine SCHEMBL29787894 | 0.86 | HTR2C (1.00) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| Nornuciferine SCHEMBL29501026 | 0.86 | HTR2C (1.00) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| SCHEMBL9976810 | 0.86 | DRD2 (0.63) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| SCHEMBL23949488 | 0.86 | DRD2 (1.00) | DRD1HTR2CPTPRCAPDRD2KDM4E | |
| SCHEMBL563496 | 0.86 | DRD2 (1.00) | DRD1HTR2CPTPRCAPDRD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140155609-A9 | QUINOLINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | DONG-A ST CO., LTD. (KR) | 2014-06-05 | — | — | US | disclosed |
| US-20130296571-A1 | QUINOLINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | DONG-A ST CO., LTD. (KR) | 2013-11-07 | — | — | US | disclosed |
| US-8202995-B2 | Pharmaceutically acceptable salts of aporphine derivatives and carboxyl group-containing agents and methods for preparing the same | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2012-06-19 | — | — | US | disclosed |
| US-8202995-B2 | Pharmaceutically acceptable salts of aporphine derivatives and carboxyl group-containing agents and methods for preparing the same | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2012-06-19 | — | — | US | disclosed |
| US-8093260-B2 | Aporphine derivatives and pharmaceutical use thereof | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2012-01-10 | — | — | US | disclosed |
| US-8093260-B2 | Aporphine derivatives and pharmaceutical use thereof | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2012-01-10 | — | — | US | disclosed |
| US-20090318488-A1 | Pharmaceutically acceprable salts of aporphine compounds of carboxyl group-containing agents and methods for preparing the same | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2009-12-24 | — | — | US | disclosed |
| US-20090318488-A1 | Pharmaceutically acceprable salts of aporphine compounds of carboxyl group-containing agents and methods for preparing the same | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2009-12-24 | — | — | US | disclosed |
| US-20090318489-A1 | Aporphine compounds and pharmaceutical use thereof | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2009-12-24 | — | — | US | disclosed |
| US-20090318489-A1 | Aporphine compounds and pharmaceutical use thereof | STANDARD CHEM. & PHARM. CO., LTD. (TW) | 2009-12-24 | — | — | US | disclosed |
| US-7294715-B2 | Aporphine and oxoaporphine compounds and pharmaceutical use thereof | LOTUS PHARMACEUTICAL CO., LTD. (TW) | 2007-11-13 | — | — | US | disclosed |
| US-7294715-B2 | Aporphine and oxoaporphine compounds and pharmaceutical use thereof | LOTUS PHARMACEUTICAL CO., LTD. (TW) | 2007-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318489-A1 | Aporphine compounds and pharmaceutical use thereof | IAPP, OPRL1, AGER | DRD1 253/4885HTR2C 89/4885PTPRCAP 1642/4885 |
| US-20090318488-A1 | Pharmaceutically acceprable salts of aporphine compounds of carboxyl group-containing agents and methods for preparing the same | IAPP, GPR119, AMY2A | DRD1 1039/4885HTR2C 389/4885PTPRCAP 715/4885 |
| US-20140155609-A9 | QUINOLINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | SLC10A2, VIP, SI | DRD1 99/4885HTR2C 349/4885PTPRCAP 4580/4885 |
| US-20130296571-A1 | QUINOLINE DERIVATIVE COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | SLC10A2, VIP, SI | DRD1 99/4885HTR2C 349/4885PTPRCAP 4580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.