Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1789380 | 0.80 | MEN1 (0.50) | KDM4EALDH1A1GAAMEN1HSD17B10 | |
| SCHEMBL27854213 | 0.74 | MAOA (0.40) | KDM4EALDH1A1GAAMEN1HSD17B10 | |
| SCHEMBL6773157 | 0.72 | CYP11B2 (0.56) | CYP11B2KDM4ECYP2A6CYP3A4ALDH1A1 | |
| SCHEMBL6439562 | 0.72 | CYP11B2 (0.56) | CYP11B2KDM4ECYP2A6CYP3A4ALDH1A1 | |
| SCHEMBL26104293 | 0.71 | MAOB (0.41) | CYP11B2KDM4EALDH1A1GAAMEN1 | |
| SCHEMBL18342012 | 0.71 | ALDH1A1 (0.40) | CYP11B2KDM4EALDH1A1GAAGLA | |
| SCHEMBL3512492 | 0.71 | CYP2A6 (0.50) | CYP11B2KDM4ECYP2A6CYP2D6CYP2C9 | |
| SCHEMBL21044401 | 0.71 | AXL (0.51) | CYP11B2KDM4ECYP2A6CYP2D6CYP2C9 | |
| SCHEMBL20240079 | 0.69 | KDM4E (0.49) | CYP11B2KDM4ECYP2A6CYP2D6CYP2C9 | |
| SCHEMBL13363883 | 0.69 | CHRNB2 (0.48) | CYP11B2KDM4ECYP2A6CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | disclosed |
| US-20070088031-A1 | Novel chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2007-04-19 | — | — | US | disclosed |
| EP-1689753-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005061516-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
| WO-2005061516-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088031-A1 | Novel chemical compounds | GSK3B, GSK3A, GSKIP | CYP11B2 1262/4885KDM4E 1488/4885CYP2A6 3116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.