Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6415752 | 0.83 | KDM4E (0.43) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL26104293 | 0.83 | MAOB (0.41) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL1789380 | 0.82 | MEN1 (0.50) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL4829289 | 0.79 | KDM4E (0.51) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL27854213 | 0.71 | MAOA (0.40) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL5635202 | 0.71 | CYP11B2 (0.45) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL12733363 | 0.69 | CYP11B2 (0.54) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL3574934 | 0.69 | CYP11B1 (0.50) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL18341896 | 0.69 | ALDH1A1 (0.51) | ALDH1A1MAPTKDM4EHPGDMEN1 | |
| SCHEMBL2959360 | 0.67 | CYP11B1 (0.44) | ALDH1A1MAPTKDM4EHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115011090-A | Degradable material and preparation method and application thereof | 万华化学（宁波）有限公司 | 2022-09-06 | — | — | CN | claimed |
| CN-115011090-B | Degradable material and preparation method and application thereof | 万华化学（宁波）有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-115011090-A | Degradable material and preparation method and application thereof | 万华化学（宁波）有限公司 | 2022-09-06 | — | — | CN | disclosed |
| CN-108137497-B | Bicyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2021-06-15 | — | — | CN | disclosed |
| EP-3313817-B1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2020-09-16 | — | — | EP | disclosed |
| US-10618909-B2 | Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2020-04-14 | — | — | US | disclosed |
| US-20190248805-A1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2019-08-15 | — | — | US | disclosed |
| US-10323041-B2 | Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2019-06-18 | — | — | US | disclosed |
| US-20180258098-A1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2018-09-13 | — | — | US | disclosed |
| EP-3313817-A1 | NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2018-05-02 | — | — | EP | disclosed |
| WO-2016207217-A1 | NEW BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2016-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10618909-B2 | Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | BAX, CASP3, CASP4 | ALDH1A1 2683/4885MAPT 2492/4885KDM4E 2880/4885 |
| US-20180258098-A1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BAX, CASP3, CASP4 | ALDH1A1 2755/4885MAPT 2516/4885KDM4E 2913/4885 |
| US-20190248805-A1 | BICYCLIC DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BAX, CASP3, CASP4 | ALDH1A1 2683/4885MAPT 2492/4885KDM4E 2880/4885 |
| US-10323041-B2 | Bicyclic derivatives, a process for their preparation and pharmaceutical compositions containing them | BAX, CASP3, CASP4 | ALDH1A1 2683/4885MAPT 2492/4885KDM4E 2880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.