Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 11/20 | 0.57 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5635251 | 1.00 | AGTR2 (0.57) | AGTR2BDKRB2ATMMMP9CTSL | |
| SCHEMBL13979529 | 0.92 | AGTR2 (0.48) | AGTR2BDKRB2MMP9CTSLCTSB | |
| SCHEMBL27224005 | 0.89 | AGTR2 (0.59) | AGTR2BDKRB2MMP9CTSLCTSB | |
| SCHEMBL9033443 | 0.89 | AGTR2 (0.59) | AGTR2BDKRB2MMP9CTSLCTSB | |
| SCHEMBL9603360 | 0.89 | AGTR2 (0.59) | AGTR2BDKRB2MMP9CTSLCTSB | |
| SCHEMBL3784713 | 0.89 | AGTR2 (0.59) | AGTR2BDKRB2MMP9CTSLCTSB | |
| SCHEMBL9033440 | 0.89 | AGTR2 (0.59) | AGTR2BDKRB2MMP9CTSLCTSB | |
| SCHEMBL13627776 | 0.87 | MMP9 (0.45) | AGTR2BDKRB2MMP9CTSLCTSB | |
| SCHEMBL7343429 | 0.87 | AGTR2 (0.53) | AGTR2ATM | |
| SCHEMBL7343432 | 0.87 | AGTR2 (0.53) | AGTR2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205384-B2 | Process for preparing peptidyl heterocyclic ketone derivatives | ORTHO-MCNEIL PHARMACEUTICAL INC. (US) | 2007-04-17 | — | — | US | disclosed |
| US-7132418-B2 | Peptidyl heterocyclic ketones useful as tryptase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| EP-1660493-A1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-31 | — | — | EP | disclosed |
| US-20050059607-A1 | Process for preparing peptidyl heterocyclic ketone derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | US | disclosed |
| WO-2005023804-A1 | PEPTIDYL HETEROCYCLIC KETONE DERIVATIVES AND PREPARATION PROCESSES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-17 | — | — | WO | disclosed |
| US-20030008829-A1 | Peptidyl heterocyclic ketones useful as tryptase inhibitors | COSTANZO MICHAEL J (US) | 2003-01-09 | — | — | US | disclosed |
| US-6469036-B1 | PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES ASSOCIATED WITH THE RESPIRATORY TRACT, SUCH AS ASTHMA AND ALLERGIC RHINITIS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-10-22 | — | — | US | disclosed |
| EP-1147097-A1 | PEPTIDYL HETEROCYCLIC KETONES USEFUL AS TRYPTASE INHIBITORS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044733-A1 | PEPTIDYL HETEROCYCLIC KETONES USEFUL AS TRYPTASE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2000-08-03 | — | — | WO | disclosed |
| US-4316906-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059607-A1 | Process for preparing peptidyl heterocyclic ketone derivatives | CMA1, TPSB2, TPSAB1 | AGTR2 344/4885BDKRB2 50/4885ATM 4254/4885 |
| US-20030008829-A1 | Peptidyl heterocyclic ketones useful as tryptase inhibitors | CMA1, TPSB2, TPSAB1 | AGTR2 1175/4885BDKRB2 59/4885ATM 2756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.