Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 8/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7169526 | 0.91 | NOTUM (0.56) | NOTUMBCHEKMT2AMEN1TSHR | |
| SCHEMBL30109103 | 0.86 | NOTUM (0.61) | NOTUMBCHEKMT2ATSHRL3MBTL1 | |
| SCHEMBL600415 | 0.86 | NOTUM (0.61) | NOTUMBCHEKMT2ATSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7492690 | 0.83 | NOTUM (0.57) | NOTUMBCHEKMT2ATSHRL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7492685 | 0.83 | NOTUM (0.57) | NOTUMBCHEKMT2AMEN1TSHR | |
| SCHEMBL18714610 | 0.82 | KMT2A (0.50) | BCHEKMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL30659324 | 0.81 | L3MBTL1 (0.46) | BCHEKMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL4795562 | 0.81 | MTNR1A (0.48) | BCHEKMT2AMEN1TSHRMAPT | |
| SCHEMBL27729357 | 0.81 | TSHR (0.47) | BCHEKMT2AMEN1TSHRL3MBTL1 | |
| SCHEMBL30546903 | 0.79 | NOTUM (0.49) | NOTUMKMT2ATSHRL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101282930-B | Fab I inhibitor and process for preparing same | CRYSTALGENOMICS INC | 2012-10-24 | — | — | CN | disclosed |
| US-7518000-B2 | Thienopyrazoles | AVENTIS PHARMACEUTICALS, INC. (US) | 2009-04-14 | — | — | US | disclosed |
| CN-101282930-A | Fab I inhibitor and process for preparing same | CRYSTALGENOMICS INC (KR) | 2008-10-08 | — | — | CN | disclosed |
| US-20070010559-A1 | Indole derivatives for use as chemical uncoupler | NOVO NORDISK A/S (DK) | 2007-01-11 | — | — | US | disclosed |
| EP-1689710-A1 | INDOLE DERIVATIVES FOR USE AS CHEMICAL UNCOUPLER | NOVO NORDISK A/S (DK) | 2006-08-16 | — | — | EP | disclosed |
| CN-1252065-C | Cinnoline compounds | ASTRAZENECA AB (SE) | 2006-04-19 | — | — | CN | disclosed |
| CN-1245402-C | indole derivatives, process for their preparation, pharmaceutical compositions containing them and their use | ASTRAZENECA AB (SE) | 2006-03-15 | — | — | CN | disclosed |
| WO-2005051908-A1 | INDOLE DERIVATIVES FOR USE AS CHEMICAL UNCOUPLER | NOVO NORDISK A/S (DK) | 2005-06-09 | — | — | WO | disclosed |
| CN-1468230-A | Compound (I) | — | 2004-01-14 | — | — | CN | disclosed |
| CN-1446214-A | Cinnoline compounds | ASTRAZENECA AB (SE) | 2003-10-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010559-A1 | Indole derivatives for use as chemical uncoupler | GPR119, IDO2, IDO1 | NOTUM 1490/4885BCHE 2543/4885KMT2A 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.