Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.48 |
| ▸ | HTR3B | O95264 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | LPO | P22079 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30109103 | 1.00 | NOTUM (0.61) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| Hydrochloric Acid SCHEMBL7492685 | 0.97 | NOTUM (0.57) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| Hydrochloric Acid SCHEMBL7492690 | 0.97 | NOTUM (0.57) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| SCHEMBL7169526 | 0.89 | NOTUM (0.56) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| SCHEMBL5635573 | 0.86 | NOTUM (0.53) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| SCHEMBL7167672 | 0.84 | P2RX4 (0.50) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| SCHEMBL30711215 | 0.82 | NOTUM (0.65) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| SCHEMBL1173678 | 0.82 | NOTUM (0.65) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| SCHEMBL7162130 | 0.82 | L3MBTL1 (0.53) | NOTUMTSHRRAB9AL3MBTL1HTR3E | |
| SCHEMBL4176193 | 0.81 | NOTUM (0.50) | NOTUMTSHRRAB9AL3MBTL1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108069918-B | Method for preparing 3-difluoromethyl isoxazole compound by one-pot method | 江西师范大学 | 2021-05-28 | — | — | CN | claimed |
| CN-102786463-B | Method for preparing 5-acetoxyl-3-indole carboxylic acid ethyl ester | ZHEJIANG GENEBEST PHARMACEUTICAL CO LTD | 2013-12-18 | — | — | CN | claimed |
| US-20130123326-A1 | ALLOSTERIC BINDING COMPOUNDS | REGION MIDTJYLLAND (DK) | 2013-05-16 | — | — | US | claimed |
| CN-102786463-A | Method for preparing 5-acetoxyl-3-indole carboxylic acid ethyl ester | ZHEJIANG GENEBEST PHARMACEUTICAL CO LTD | 2012-11-21 | — | — | CN | claimed |
| US-20120095048-A1 | ALLOSTERIC BINDING COMPOUNDS | REGION MIDT JYLLAND (DK) | 2012-04-19 | — | — | US | claimed |
| EP-2398760-A1 | ALLOSTERIC BINDING COMPOUNDS | Aarhus Universitet (DK) | 2011-12-28 | — | — | EP | claimed |
| WO-2010094289-A1 | ALLOSTERIC BINDING COMPOUNDS | AARHUS UNIVERSITET (DK) | 2010-08-26 | — | — | WO | claimed |
| US-7632956-B2 | Fragrance ingredients, applications, compositions and methods | GIVAUDAN SA (CH) | 2009-12-15 | — | — | US | claimed |
| US-20090036690-A1 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2009-02-05 | — | — | US | claimed |
| EP-1799797-B1 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2008-05-14 | — | — | EP | claimed |
| EP-1799797-A1 | ORGANIC COMPOUNDS | Givaudan SA (CH) | 2007-06-27 | — | — | EP | claimed |
| WO-2006039822-A1 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2006-04-20 | — | — | WO | claimed |
| EP-1335917-A2 | CONDENSED PYRIDOINDOLE DERIVATIVES | Lilly Icos LLC (US) | 2003-08-20 | — | — | EP | claimed |
| WO-2002028859-A2 | CONDENSED PYRIDOINDOLE DERIVATIVES | LILLY ICOS LLC (US) | 2002-04-11 | — | — | WO | claimed |
| CN-113181362-B | Medicament for preventing and/or treating amyotrophic lateral sclerosis | 国立大学法人京都大学 | 2023-06-13 | — | — | CN | disclosed |
| CN-108530335-B | Indole compound and preparation method and application thereof | 华南农业大学 | 2021-08-31 | — | — | CN | disclosed |
| CN-107963996-B | Method for preparing 3-trifluoromethyl isoxazole compound by one-pot method | 江西师范大学 | 2021-06-11 | — | — | CN | disclosed |
| WO-2000058286-A2 | METHOD OF PRODUCING HETEROCYCLIC CARBAMATES FROM AZA-HETEROCYCLIC COMPOUNDS AND CARBON DIOXIDE | Gödecke GmbH (DE) | 2000-10-05 | — | — | WO | disclosed |
| EP-1001934-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999005104-A1 | INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036690-A1 | ORGANIC COMPOUNDS | TRPA1, IDO1, INMT | NOTUM 68/4885TSHR 3438/4885RAB9A 4023/4885 |
| US-20120095048-A1 | ALLOSTERIC BINDING COMPOUNDS | GRIN2C, GRM2, GRIN2B | NOTUM 4008/4885TSHR 534/4885RAB9A 1225/4885 |
| US-20130123326-A1 | ALLOSTERIC BINDING COMPOUNDS | GRIN2C, GRM2, GRIN2B | NOTUM 4008/4885TSHR 534/4885RAB9A 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.