Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14514081 | 0.84 | SMN1; SMN2 (0.70) | TSHRHTTSMN1; SMN2GAATHRB | |
| SCHEMBL315267 | 0.81 | MAPT (0.44) | HTTSMN1; SMN2GAATHRBMAPT | |
| SCHEMBL5633461 | 0.77 | HDAC3 (0.62) | TSHRMAPTTNKSPARP1PARP2 | |
| SCHEMBL16400168 | 0.77 | LMNA (0.40) | HTTSMN1; SMN2GAATHRBMAPT | |
| SCHEMBL13543047 | 0.77 | PLAT (0.48) | TSHRSMN1; SMN2THRBMAPTTNKS | |
| SCHEMBL315752 | 0.76 | PKM (0.42) | HTTSMN1; SMN2GAATHRBMAPT | |
| SCHEMBL314794 | 0.76 | ENPP2 (0.46) | HTTSMN1; SMN2GAATHRBMAPT | |
| SCHEMBL2709521 | 0.76 | SMN1; SMN2 (0.55) | HTTSMN1; SMN2GAATHRBNPC1 | |
| SCHEMBL315417 | 0.74 | ENPP2 (0.48) | HTTSMN1; SMN2GAATHRBMAPT | |
| SCHEMBL314745 | 0.74 | L3MBTL1 (0.41) | HTTSMN1; SMN2GAATHRBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7217714-B1 | CCR5 modulators | AGOURON PHARMACEUTICALS, INC. (US) | 2007-05-15 | — | — | US | disclosed |