SCHEMBL563872

SCHEMBL563872

Nc1cc(Nc2ccc(O)cc2)ccc1O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 9/20 0.61
ALOX15 P16050 4/20 0.61
RECQL P46063 4/20 0.61
TDP1 Q9NUW8 3/20 0.61
CYP3A4 P08684 2/20 0.61
HIF1A Q16665 2/20 0.61
THRB P10828 2/20 0.61
TSHR P16473 1/20 0.45
HSD17B10 Q99714 4/20 0.43
ALOX12 P18054 3/20 0.43
HPGD P15428 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
MAPK1 P28482 1/20 0.43
GAA P10253 7/20 0.42
MAPT P10636 6/20 0.42
MEN1 O00255 5/20 0.42
KMT2A Q03164 5/20 0.42
KDM4E B2RXH2 3/20 0.42
GFER P55789 1/20 0.42
ATM Q13315 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL564678 0.91 ALDH1A1 (0.50) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL564746 0.88 ALDH1A1 (0.50) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL564969 0.86 CYP3A4 (0.59) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL563902 0.84 CYP3A4 (0.62) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL563875 0.83 CYP3A4 (0.67) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL19152170 0.81 ALDH1A1 (0.42) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL564967 0.79 MAPT (0.60) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL1921921 0.76 ALDH1A1 (0.57) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL306231 0.76 ALDH1A1 (0.57) ALDH1A1ALOX15RECQLTDP1CYP3A4
SCHEMBL8092870 0.76 TDP1 (1.00) ALDH1A1ALOX15RECQLTDP1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8674029-B2 Method of preparing stabilized polymeric systems using polymeric peroxides Sunocs LLC (US) 2014-03-18 US disclosed
US-20120035307-A1 PROCESS FOR MAKING STABLIZED POLYMERIC SYSTEMS WITH NANOSTRUCTURES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-20120035315-A1 METHOD OF PREPARING STABLIZED POLYMERIC SYSTEMS USING POLYMERIC PEROXIDES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-7498467-B2 Antioxidant and bisaminophenol derivative IDEMITSU KOSAN CO., LTD. (JP) 2009-03-03 US disclosed
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN CO., LTD. (JP) 2008-07-03 US disclosed
US-20060208227-A1 Antioxidant and bisaminophenol derivative IDEMITSU LOSAN CO., LTD (JP) 2006-09-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE CBR1, CBR3, HMOX1 ALDH1A1 204/4885ALOX15 1352/4885RECQL 294/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.