SCHEMBL564678

SCHEMBL564678

Nc1cc(Nc2ccc(O)c(N)c2)ccc1O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.50
ALOX15 P16050 7/20 0.50
HSD17B10 Q99714 6/20 0.50
ALOX12 P18054 3/20 0.50
HPGD P15428 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
MAPK1 P28482 1/20 0.50
RECQL P46063 3/20 0.48
THRB P10828 3/20 0.48
CYP3A4 P08684 3/20 0.48
HIF1A Q16665 2/20 0.48
TDP1 Q9NUW8 2/20 0.48
GAA P10253 8/20 0.45
MAPT P10636 4/20 0.45
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
HTT P42858 2/20 0.45
KDM4E B2RXH2 2/20 0.45
USP2 O75604 2/20 0.45
PKM P14618 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL563872 0.91 ALDH1A1 (0.61) ALDH1A1ALOX15HSD17B10ALOX12HPGD
SCHEMBL564746 0.91 ALDH1A1 (0.50) ALDH1A1ALOX15HSD17B10ALOX12HPGD
SCHEMBL564969 0.89 CYP3A4 (0.59) ALDH1A1ALOX15HSD17B10ALOX12HPGD
SCHEMBL563902 0.88 CYP3A4 (0.62) ALDH1A1ALOX15HSD17B10ALOX12MAPK1
SCHEMBL564967 0.86 MAPT (0.60) ALDH1A1ALOX15HSD17B10ALOX12HPGD
SCHEMBL19152170 0.84 ALDH1A1 (0.42) ALDH1A1ALOX15HSD17B10ALOX12HPGD
SCHEMBL27870146 0.83 ALDH1A1 (0.48) ALDH1A1ALOX15HSD17B10ALOX12HPGD
SCHEMBL13537486 0.83 ALDH1A1 (0.48) ALDH1A1ALOX15HSD17B10ALOX12HPGD
SCHEMBL17558924 0.82 ALOX15 (0.45) ALDH1A1ALOX15HSD17B10ALOX12HPGD
SCHEMBL11118502 0.82 AKR1C3 (0.48) ALDH1A1SMN1; SMN2RECQLGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8871894-B2 Production method of polyhydroxyimide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-10-28 US disclosed
US-8796393-B2 Production method of polyhydroxyimide and positive photosensitive resin composition containing polyhydroxyimide obtained by the production method NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-08-05 US disclosed
US-8674029-B2 Method of preparing stabilized polymeric systems using polymeric peroxides Sunocs LLC (US) 2014-03-18 US disclosed
US-20130131282-A1 PRODUCTION METHOD OF POLYHYDROXYIMIDE AND POSITIVE PHOTOSENSITIVE RESIN COMPOSITION CONTAINING POLYHYDROXYIMIDE OBTAINED BY THE PRODUCTION METHOD NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-05-23 US disclosed
US-20120094232-A1 PRODUCTION METHOD OF POLYHYDROXYIMIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-04-19 US disclosed
US-20120035307-A1 PROCESS FOR MAKING STABLIZED POLYMERIC SYSTEMS WITH NANOSTRUCTURES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-20120035315-A1 METHOD OF PREPARING STABLIZED POLYMERIC SYSTEMS USING POLYMERIC PEROXIDES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-7498467-B2 Antioxidant and bisaminophenol derivative IDEMITSU KOSAN CO., LTD. (JP) 2009-03-03 US disclosed
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN CO., LTD. (JP) 2008-07-03 US disclosed
US-20060208227-A1 Antioxidant and bisaminophenol derivative IDEMITSU LOSAN CO., LTD (JP) 2006-09-21 US disclosed
EP-1612254-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN COMPANY LIMITED (JP) 2006-01-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE CBR1, CBR3, HMOX1 ALDH1A1 204/4885ALOX15 1352/4885HSD17B10 317/4885
US-20120094232-A1 PRODUCTION METHOD OF POLYHYDROXYIMIDE GRHPR, MRPL21, F12 ALDH1A1 4101/4885ALOX15 4426/4885HSD17B10 2033/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.