Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.58 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.58 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NNMT | P40261 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782132 | 0.87 | EPHX2 (0.56) | EPHX2NR1H4PPARGHDAC3HDAC1 | |
| SCHEMBL3962896 | 0.86 | LMNA (0.60) | EPHX2NR1H4PPARG | |
| SCHEMBL5645497 | 0.86 | ROCK2 (0.58) | EPHX2NR1H4P2RX7 | |
| SCHEMBL5643140 | 0.85 | EPHX2 (0.54) | EPHX2NR1H4PPARGMAOB | |
| SCHEMBL3460904 | 0.85 | EPHX2 (0.57) | EPHX2NR1H4PPARGHDAC1MAOB | |
| SCHEMBL18067725 | 0.82 | HPGD (0.59) | EPHX2NR1H4P2RX7HDAC1HPGD | |
| SCHEMBL13947127 | 0.82 | HPGD (0.64) | HPGDMAPT | |
| SCHEMBL20365215 | 0.82 | EPHX2 (0.76) | EPHX2NR1H4PPARGHDAC3MAPT | |
| SCHEMBL678099 | 0.81 | CA2 (0.70) | EPHX2NR1H4 | |
| SCHEMBL3568253 | 0.79 | P2RX7 (0.53) | EPHX2NR1H4PPARGP2RX7MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241759-B2 | Benzo[1,2,5]thiadiazole compounds | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-10 | — | — | US | disclosed |