Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2251695 | 0.92 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2KDM4EKMT2AHDAC1 | |
| SCHEMBL2251183 | 0.89 | MAPT (0.44) | MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2252347 | 0.88 | TUBB4A (0.41) | MAPTSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2247761 | 0.87 | MAPT (0.41) | MAPTSMN1; SMN2KMT2AHDAC1HDAC8 | |
| SCHEMBL2247389 | 0.86 | SMPD1 (0.42) | SMN1; SMN2HDAC1HDAC8PDE4BPDE4D | |
| SCHEMBL2247654 | 0.85 | SMN1; SMN2 (0.42) | MAPTSMN1; SMN2KDM4EKMT2AHDAC1 | |
| SCHEMBL2248001 | 0.85 | KDM4E (0.40) | MAPTSMN1; SMN2KDM4EKMT2AHDAC1 | |
| SCHEMBL2254247 | 0.85 | SMN1; SMN2 (0.40) | MAPTSMN1; SMN2KMT2AHDAC1PDE4B | |
| SCHEMBL2247223 | 0.85 | MAPT (0.41) | MAPTKMT2AHDAC1MEN1 | |
| SCHEMBL2246937 | 0.85 | RXRA (0.43) | MAPTSMN1; SMN2KDM4EKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | MAPT 1544/4885SMN1; SMN2 2624/4885PSMB5 2033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.