Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5651048 | 0.88 | CES2 (0.65) | CES2CES1L3MBTL1POLBMAPT | |
| SCHEMBL8378857 | 0.82 | KMT2A (0.53) | CES2CES1L3MBTL1TDP1RAB9A | |
| SCHEMBL28305665 | 0.81 | ALDH1A1 (0.49) | CES2CES1L3MBTL1POLBMAPT | |
| SCHEMBL576239 | 0.80 | KMT2A (0.39) | CES2CES1POLBMAPTRAB9A | |
| SCHEMBL775621 | 0.80 | NPC1 (0.61) | CES2CES1POLBMAPTTDP1 | |
| SCHEMBL23497897 | 0.79 | F2 (0.45) | CES2CES1POLBMAPTTDP1 | |
| SCHEMBL28637523 | 0.79 | CES2 (0.52) | CES2CES1POLBMAPTTDP1 | |
| SCHEMBL5649620 | 0.79 | PKM (0.61) | CES2CES1RAB9APKMNPC1 | |
| SCHEMBL158348 | 0.79 | CES2 (0.59) | CES2CES1L3MBTL1MAPTTDP1 | |
| SCHEMBL29765677 | 0.79 | CES2 (0.59) | CES2CES1L3MBTL1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |
| US-4255594-A | Hydrogenation of halogen-containing carboxylic anhydrides | ALLIED CHEMICAL CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |