Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.42 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 10/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5650258 | 0.84 | LMNA (0.38) | SMN1; SMN2ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL5651454 | 0.79 | ALDH1A1 (0.54) | SMN1; SMN2TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL2781580 | 0.74 | CNR2 (0.43) | SMN1; SMN2NPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL5651499 | 0.74 | MDM2 (0.51) | SMN1; SMN2CYP2C19ALDH1A1CYP2D6CYP2C9 | |
| SCHEMBL5648783 | 0.74 | LMNA (0.45) | SMN1; SMN2NPC1RAB9ATSHRALDH1A1 | |
| SCHEMBL5653013 | 0.73 | GABRA1 (0.47) | SMN1; SMN2NPC1RAB9AALDH1A1HSD17B10 | |
| SCHEMBL5651257 | 0.73 | NMT1 (0.40) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL1266481 | 0.72 | CNR2 (0.40) | SMN1; SMN2NPC1RAB9ACYP2C19TSHR | |
| SCHEMBL2782594 | 0.72 | CNR2 (0.38) | SMN1; SMN2CYP2C19ALDH1A1CYP2C9KDM4E | |
| SCHEMBL5651409 | 0.72 | ALDH1A1 (0.45) | SMN1; SMN2CYP2C19ALDH1A1HSD17B10CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176215-B2 | Bicyclic oxopyridine and oxopyrimidine derivatives | CELLTECH R&D LIMITED (GB) | 2007-02-13 | — | — | US | disclosed |
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | UCB PHARMA S.A. (BE) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254200-A1 | Bicyclic oxopyridine and oxopyrimidine derivatives | MAPK1, ALK, NAT1 | SMN1; SMN2 3476/4885NPC1 1606/4885RAB9A 3641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.