SCHEMBL565190

SCHEMBL565190

Nc1cccc(-c2ccc(O)c(N)c2)c1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.70
ALOX15 P16050 2/20 0.70
HSD17B10 Q99714 2/20 0.70
MEN1 O00255 2/20 0.70
KDM4E B2RXH2 1/20 0.70
USP2 O75604 1/20 0.70
LMNA P02545 1/20 0.70
HSP90AA1 P07900 1/20 0.70
GAA P10253 1/20 0.70
MAPT P10636 1/20 0.70
HPGD P15428 1/20 0.70
ALOX12 P18054 1/20 0.70
HTT P42858 1/20 0.70
KMT2A Q03164 1/20 0.70
MCL1 Q07820 1/20 0.61
MAOA P21397 1/20 0.56
CYP3A4 P08684 4/20 0.55
HSD17B1 P14061 4/20 0.55
HSD17B2 P37059 4/20 0.55
CYP2C9 P11712 2/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29488306 0.89 ALOX15 (0.79) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL16949917 0.89 ALOX15 (0.79) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL565655 0.85 KDM4E (0.73) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL8063212 0.85 APP (0.71) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL29367250 0.84 ALDH1A1 (0.77) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL108713 0.84 ALDH1A1 (0.77) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL28822417 0.84 ALDH1A1 (0.77) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL564901 0.83 CYP3A4 (0.71) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL29879392 0.83 ALOX15 (1.00) ALDH1A1ALOX15HSD17B10MEN1KDM4E
SCHEMBL305617 0.83 ALOX15 (1.00) ALDH1A1ALOX15HSD17B10MEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160053116-A1 POLYMER SOLUTION, POLYMER FILM, STACKED COMPOSITE, DISPLAY ELEMENT, OPTICAL ELEMENT, ILLUMINATION ELEMENT, AND PRODUCTION METHOD THEREFOR SUMITOMO BAKELITE CO., LTD. (JP) 2016-02-25 US disclosed
US-8674029-B2 Method of preparing stabilized polymeric systems using polymeric peroxides Sunocs LLC (US) 2014-03-18 US disclosed
US-20120035307-A1 PROCESS FOR MAKING STABLIZED POLYMERIC SYSTEMS WITH NANOSTRUCTURES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-20120035315-A1 METHOD OF PREPARING STABLIZED POLYMERIC SYSTEMS USING POLYMERIC PEROXIDES SONG CHENGQIAN (US) 2012-02-09 US disclosed
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
US-7498467-B2 Antioxidant and bisaminophenol derivative IDEMITSU KOSAN CO., LTD. (JP) 2009-03-03 US disclosed
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN CO., LTD. (JP) 2008-07-03 US disclosed
EP-1914221-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2008-04-23 EP disclosed
US-20060208227-A1 Antioxidant and bisaminophenol derivative IDEMITSU LOSAN CO., LTD (JP) 2006-09-21 US disclosed
EP-1612254-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE IDEMITSU KOSAN COMPANY LIMITED (JP) 2006-01-04 EP disclosed
US-6524770-B1 For polyimide precursor curable under patternwise low radiation; heat and chemical resistance; polyamide having unsaturated ester pendant groups cures HITACHI CHEMICAL CO., LTD. (JP) 2003-02-25 US disclosed
EP-0431971-B1 Photosensitive composition and resin-encapsulated semiconductor device TOSHIBA KK (JP) 1995-07-19 EP disclosed
US-5340684-A Polyimidesiloxane copolymers KABUSHIKI KAISHA TOSHIBA (JP) 1994-08-23 US disclosed
EP-0431971-A2 Photosensitive composition and resin-encapsulated semiconductor device KABUSHIKI KAISHA TOSHIBA (JP) 1991-06-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161608-A1 ANTIOXIDANT AND BISAMINOPHENOL DERIVATIVE CBR1, CBR3, HMOX1 ALDH1A1 204/4885ALOX15 1352/4885HSD17B10 317/4885
US-20100087680-A1 METHOD FOR PRODUCING BIARYL COMPOUND NISCH, BLVRB, BBOX1 ALDH1A1 4339/4885ALOX15 1941/4885HSD17B10 1100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.