Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 6/20 | 0.47 |
| ▸ | ITGB7 | P26010 | 6/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5274482 | 0.83 | AKR1C1 (0.56) | P2RX7ALDH1A1LMNANPSR1CYP2D6 | |
| SCHEMBL2593341 | 0.82 | ITGA4 (0.48) | ITGA4ITGB7P2RX7ALDH1A1IDO1 | |
| SCHEMBL25062470 | 0.78 | ALDH1A1 (0.47) | ITGA4ITGB7P2RX7ALDH1A1IDO1 | |
| SCHEMBL30475673 | 0.78 | ALDH1A1 (0.47) | ITGA4ITGB7P2RX7ALDH1A1IDO1 | |
| SCHEMBL25460767 | 0.77 | ALDH1A1 (0.53) | ITGA4ITGB7P2RX7ALDH1A1IDO1 | |
| SCHEMBL7010865 | 0.77 | ALDH1A1 (0.47) | ITGA4ITGB7P2RX7ALDH1A1IDO1 | |
| SCHEMBL14232824 | 0.77 | SLC6A2 (0.44) | P2RX7ALDH1A1IDO1LMNAMEN1 | |
| SCHEMBL25062469 | 0.77 | OPRM1 (0.53) | P2RX7ALDH1A1LMNACYP2D6APOBEC3A | |
| SCHEMBL29430547 | 0.77 | OPRM1 (0.53) | P2RX7ALDH1A1LMNACYP2D6APOBEC3A | |
| SCHEMBL9338162 | 0.76 | AKR1C1 (0.65) | ITGA4ITGB7P2RX7ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006033844-A9 | 4-ARYLSPIROCYCLOALKYL-2-AMINOPYRIMIDINE CARBOXAMIDE KCNQ POTASSIUM CHANNEL MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2007-10-25 | — | — | WO | disclosed |
| US-7091202-B2 | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-08-15 | — | — | US | disclosed |
| US-20060063790-A1 | 4-Arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | BRISTOL-MYERS SQUIBB COMPANY | 2006-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063790-A1 | 4-Arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators | KCNQ2, KCNQ1, KCNQ4 | ITGA4 2084/4885ITGB7 4114/4885P2RX7 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.