Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652633 | 0.80 | KMT2A (0.54) | HPGDCYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL6106401 | 0.78 | FADS1 (0.59) | SMN1; SMN2KDM4EALDH1A1POLBRAB9A | |
| SCHEMBL27804869 | 0.77 | KMT2A (0.53) | HPGDCYP1A2CYP2C19SMN1; SMN2KDM4E | |
| SCHEMBL678202 | 0.77 | LMNA (0.55) | CYP1A2CYP2C19SMN1; SMN2JAK2TYK2 | |
| SCHEMBL5648375 | 0.76 | NPC1 (0.54) | HPGDCYP2C19SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL6819083 | 0.76 | SMO (0.71) | HPGDCYP1A2CYP2C19SMN1; SMN2JAK2 | |
| SCHEMBL24074617 | 0.75 | SMN1; SMN2 (0.52) | HPGDCYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL12190166 | 0.75 | CYP11B2 (0.63) | SMN1; SMN2ALDH1A1JAK2TYK2GRM4 | |
| SCHEMBL821907 | 0.73 | RAB9A (0.58) | HPGDCYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL5649097 | 0.73 | KCNQ3 (0.61) | HPGDCYP1A2CYP2C19SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |