Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PGK1 | P00558 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29757749 | 1.00 | TSHR (0.45) | TSHRMAPK1TDP1GPR35ALDH1A1 | |
| SCHEMBL20265347 | 0.83 | TSHR (0.42) | TSHRMAPK1TDP1GPR35ALDH1A1 | |
| SCHEMBL456768 | 0.82 | ALDH1A1 (0.44) | TSHRMAPK1TDP1GPR35ALDH1A1 | |
| SCHEMBL7585436 | 0.81 | VCAM1 (0.41) | TSHRMAPK1TDP1GPR35ALDH1A1 | |
| SCHEMBL30242608 | 0.79 | CYP1A2 (0.44) | TSHRMAPK1TDP1GPR35ALDH1A1 | |
| SCHEMBL26094505 | 0.79 | KEAP1 (0.44) | TSHRMAPK1TDP1GPR35ALDH1A1 | |
| SCHEMBL1625327 | 0.79 | CYP1A2 (0.44) | TSHRMAPK1TDP1GPR35ALDH1A1 | |
| SCHEMBL22596350 | 0.77 | MERTK (0.43) | TSHRMAPK1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL29757772 | 0.77 | MERTK (0.43) | TSHRMAPK1TDP1ALDH1A1CYP3A4 | |
| SCHEMBL9686971 | 0.76 | TSHR (0.47) | TSHRMAPK1TDP1GPR35ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11767320-B2 | Bicyclic dione compounds as inhibitors of KRAS | INCYTE CORPORATION (US) | 2023-09-26 | — | — | US | disclosed |
| CN-113166103-B | EGFR inhibitor and application thereof | 江苏先声药业有限公司 | 2022-12-16 | — | — | CN | disclosed |
| CN-114728932-A | Polyarylates as EGFR kinase inhibitors | 江苏先声药业有限公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2022072783-A1 | BICYCLIC DIONE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION (US) | 2022-04-07 | — | — | WO | disclosed |
| US-20220106309-A1 | BICYCLIC DIONE COMPOUNDS AS INHIBITORS OF KRAS | INCYTE CORPORATION | 2022-04-07 | — | — | US | disclosed |
| CN-113166103-A | EGFR inhibitor and application thereof | 江苏先声药业有限公司 | 2021-07-23 | — | — | CN | disclosed |
| WO-2021104441-A1 | POLYAROMATIC COMPOUND AS EGFR KINASE INHIBITOR | 江苏先声药业有限公司 | 2021-06-03 | — | — | WO | disclosed |
| WO-2020216371-A1 | EGFR INHIBITOR AND APPLICATION THEREOF | 江苏先声药业有限公司 | 2020-10-29 | — | — | WO | disclosed |
| WO-2020216371-A1 | EGFR INHIBITOR AND APPLICATION THEREOF | 江苏先声药业有限公司 | 2020-10-29 | — | — | WO | disclosed |
| US-10442808-B2 | Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors | NOVARTIS AG (CH) | 2019-10-15 | — | — | US | disclosed |
| US-20020077329-A1 | EP4 receptor inhibitors to treat rheumatoid arthritis | PFIZER PHARMACEUTICALS INC. (JP) | 2002-06-20 | — | — | US | disclosed |
| WO-2002032900-A2 | ARYL OR HETEROARYL FUSED IMIDAZOLE COMPOUNDS AS ANTI-INFLAMMATORY AND ANALGESIC AGENTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |
| US-5811432-A | Azaoxindole derivatives | PFIZER INC (US) | 1998-09-22 | — | — | US | disclosed |
| CN-1031053-C | Azaoxindole derivatives | PFIZER (US) | 1996-02-21 | — | — | CN | disclosed |
| CN-1053065-A | AZAOXINDOLE DERIVATIVES | PFIZER (US) | 1991-07-17 | — | — | CN | disclosed |
| WO-1991009598-A1 | AZAOXINDOLE DERIVATIVES | PFIZER INC. (US) | 1991-07-11 | — | — | WO | disclosed |
| EP-0436333-A2 | Azaoxindole derivatives | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |
| US-4521603-A | Continuous process for the production of polybromopyridine compounds | OLIN CORPORATION (US) | 1985-06-04 | — | — | US | disclosed |
| US-3974166-A | FUNGICIDE | CIBA-GEIGY CORPORATION (US) | 1976-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11767320-B2 | Bicyclic dione compounds as inhibitors of KRAS | KRAS, NRAS, HRAS | TSHR 4625/4885MAPK1 296/4885TDP1 2025/4885 |
| US-20020077329-A1 | EP4 receptor inhibitors to treat rheumatoid arthritis | PTGER4, PTGER1, PTGER2 | TSHR 351/4885MAPK1 1556/4885TDP1 3985/4885 |
| US-20220106309-A1 | BICYCLIC DIONE COMPOUNDS AS INHIBITORS OF KRAS | KRAS, NRAS, HRAS | TSHR 4625/4885MAPK1 296/4885TDP1 2025/4885 |
| US-10442808-B2 | Pyrazolo pyrimidine derivatives and their use as MALT1 inhbitors | FBP1, MMEL1, MALT1 | TSHR 4836/4885MAPK1 476/4885TDP1 358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.