Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | AGXT | P21549 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 3/20 | 0.47 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5649684 | 0.84 | CYP17A1 (0.43) | MPOMAOBIDO1AGXTDHFR | |
| SCHEMBL5648620 | 0.84 | L3MBTL1 (0.47) | HPGDPIN1MPOMAOBCYP3A4 | |
| SCHEMBL5652395 | 0.78 | PIN1 (0.45) | KDM4EPIN1MPOMAOBAGXT | |
| SCHEMBL5651640 | 0.75 | MAOB (0.49) | MPOMAOBIDO1AGXTMAPT | |
| SCHEMBL5026708 | 0.75 | CYP3A4 (0.51) | PIN1MPOMAOBCYP3A4IDO1 | |
| SCHEMBL1577872 | 0.74 | MAOB (0.60) | MAOBCYP3A4IDO1AGXTGRM5 | |
| SCHEMBL6286452 | 0.72 | PIN1 (0.52) | KDM4EHPGDPIN1MPOMAOB | |
| SCHEMBL7539477 | 0.71 | SYK (0.49) | — | |
| SCHEMBL24316986 | 0.71 | KDM4E (0.50) | KDM4EHPGDMAOBCYP3A4GRM5 | |
| SCHEMBL5653373 | 0.71 | ALOX5AP (0.39) | MPOMAOBDHFRFFAR1DCPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |