Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.49 |
| ▸ | MGMT | P16455 | 2/20 | 0.45 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652395 | 0.88 | PIN1 (0.45) | MAOBMPOMAPTAGXTMEN1 | |
| SCHEMBL5649684 | 0.85 | CYP17A1 (0.43) | MAOBMPOLMNAMAPTPOLB | |
| SCHEMBL5648620 | 0.84 | L3MBTL1 (0.47) | MAOBMGMTMPOLMNAMAPT | |
| Hydrochloric Acid SCHEMBL15669833 | 0.82 | MAOB (0.53) | MAOBMGMTMPOLMNAMAPT | |
| SCHEMBL15669834 | 0.81 | FFAR1 (0.41) | MAOBMGMTLMNAMAPTPOLB | |
| SCHEMBL15351339 | 0.80 | LMNA (0.39) | MAOBMGMTMPOLMNAMAPT | |
| SCHEMBL5650853 | 0.79 | RAB9A (0.41) | LMNAPOLBHTTSMN1; SMN2MEN1 | |
| SCHEMBL15351722 | 0.77 | MAOB (0.56) | MAOBMEN1KMT2AKDM5AKDM4C | |
| SCHEMBL15350256 | 0.77 | KDM5A (0.54) | MAOBKDM5AKDM4CKDM5B | |
| SCHEMBL21078951 | 0.76 | MAOB (0.38) | MAOBMGMTLMNAMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |