Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | TEC | P42680 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5652395 | 0.88 | PIN1 (0.45) | MAPTMAOBAGXTMPOHRH4 | |
| SCHEMBL5651640 | 0.85 | MAOB (0.49) | LMNAMAPTHTTSMN1; SMN2MAOB | |
| SCHEMBL5648620 | 0.84 | L3MBTL1 (0.47) | LMNAMAPTHTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL5655538 | 0.84 | KDM4E (0.54) | MAPTMAOBIDO1AGXTDHFR | |
| SCHEMBL18072325 | 0.76 | NUDT1 (0.53) | CYP17A1LMNAMAPTHTTSMN1; SMN2 | |
| SCHEMBL4061661 | 0.74 | CYP1A2 (0.52) | SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL5650853 | 0.73 | RAB9A (0.41) | LMNAHTTSMN1; SMN2L3MBTL1POLB | |
| SCHEMBL3378270 | 0.73 | TSHR (0.38) | MAPTL3MBTL1POLB | |
| SCHEMBL7539477 | 0.72 | SYK (0.49) | L3MBTL1HRH4 | |
| SCHEMBL4323959 | 0.71 | MAOB (0.54) | MAOBIDO1AGXTDHFRTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7235559-B1 | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-06-26 | — | — | US | disclosed |
| CN-1391563-A | Therapeutic quinazoline derivatives | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | CN | disclosed |
| EP-1218355-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021597-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-29 | — | — | WO | disclosed |