SCHEMBL565555

SCHEMBL565555

Nc1c(O)cccc1-c1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.62
HSD17B10 Q99714 3/20 0.62
HPGD P15428 2/20 0.62
BCL2L1 Q07817 1/20 0.62
BACE1 P56817 1/20 0.52
BRD4 O60885 1/20 0.50
NR1I2 O75469 1/20 0.50
SMARCA2 P51531 1/20 0.50
SMARCA4 P51532 1/20 0.50
PBRM1 Q86U86 1/20 0.50
ALOX15 P16050 3/20 0.47
TSHR P16473 2/20 0.47
ADORA3 P0DMS8 1/20 0.47
ADORA2A P29274 1/20 0.47
ADORA2B P29275 1/20 0.47
ADORA1 P30542 1/20 0.47
G6PD P11413 1/20 0.47
CASP7 P55210 1/20 0.47
CASP6 P55212 1/20 0.47
MAPT P10636 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31310694 1.00 ALDH1A1 (0.62) ALDH1A1HSD17B10HPGDBCL2L1BACE1
SCHEMBL3789766 0.84 ALDH1A1 (0.43) ALDH1A1HSD17B10HPGDBCL2L1BRD4
SCHEMBL1822460 0.83 ALDH1A1 (0.62) ALDH1A1HSD17B10HPGDBCL2L1BACE1
SCHEMBL564030 0.83 CASP7 (0.50) ALDH1A1HSD17B10HPGDBCL2L1ALOX15
SCHEMBL28236406 0.82 BACE1 (0.52) ALDH1A1HSD17B10HPGDBCL2L1BACE1
SCHEMBL16986786 0.81 SMN1; SMN2 (0.48) ALDH1A1HSD17B10HPGDBCL2L1BRD4
SCHEMBL11371726 0.81 MAPT (0.44) ALDH1A1HSD17B10HPGDBCL2L1BRD4
SCHEMBL3790386 0.81 MAP4K4 (0.50) ALDH1A1HSD17B10HPGDBCL2L1MAPT
SCHEMBL6247748 0.81 PTGS2 (0.46) ALDH1A1HSD17B10HPGDBCL2L1ALOX15
SCHEMBL30439996 0.81 HSD17B1 (0.50) ALDH1A1HSD17B10ADORA1LMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117247515-A Polyimide containing Trringer's Base element and gas separation membrane and method prepared by polyimide 西北工业大学 2023-12-19 CN claimed
CN-116854913-A Preparation method of high-impact-resistance bismaleimide resin 西北工业大学 2023-10-10 CN claimed
CN-116854679-A Novel epoxy resin containing imide unit and preparation method thereof 西北工业大学 2023-10-10 CN claimed
CN-104812823-B With the crosslinked rubber composition of low resin 米其林集团总公司 2018-10-23 CN claimed
CN-104684988-B Rubber composition with multiple reinforced resins 米其林集团总公司 2017-07-11 CN claimed
CN-104812823-A Rubber composition with low resin crosslinking MICHELIN & CIE 2015-07-29 CN claimed
CN-104684988-A Rubber composition with multiple reinforced resins MICHELIN & CIE 2015-06-03 CN claimed
CN-101151579-B Photosensitive resin composition and circuit board using the same NIPPON STEEL CHEMICAL CO 2010-10-06 CN claimed
CN-101400699-A Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions BRISTOL MYERS SQUIBB CO (US) 2009-04-01 CN claimed
US-11999695-B2 YAP1 inhibitors that target the interaction of YAP1 with OCT4 H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2024-06-04 US disclosed
CN-115108994-B Tergolian intermediate and preparation method and application thereof 江苏威奇达药业有限公司 2024-05-31 CN disclosed
CN-117247515-A Polyimide containing Trringer's Base element and gas separation membrane and method prepared by polyimide 西北工业大学 2023-12-19 CN disclosed
CN-115124485-B Sulfoxide-containing benzoxazole derivative, and preparation method and application thereof 中国医学科学院药物研究所 2023-12-15 CN disclosed
CN-116854679-A Novel epoxy resin containing imide unit and preparation method thereof 西北工业大学 2023-10-10 CN disclosed
US-5219981-A Semi-continuous process for synthesis of polybenzazole polymers THE DOW CHEMICAL COMPANY (US) 1993-06-15 US disclosed
US-5194568-A Polybenzimidazoles, polybenzoxazoles, polybenzothiazoles, oligomerization, chain extension THE DOW CHEMICAL COMPANY (US) 1993-03-16 US disclosed
EP-0481402-A2 Staged polymerization of polybenzazole polymers THE DOW CHEMICAL COMPANY (US) 1992-04-22 EP disclosed
EP-0481403-A1 Rapid advancement of molecular weight in polybenzazole oligomer solutions THE DOW CHEMICAL COMPANY (US) 1992-04-22 EP disclosed
US-5089591-A Polymerizing under shear in solvent acid solution THE DOW CHEMICAL COMPANY (US) 1992-02-18 US disclosed
US-4064136-A FROM A NITRILE, AN ALCOHOL AND ORTHO-SUBSTITUTED AROMATIC AMINE CIBA-GEIGY AG (CH) 1977-12-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11999695-B2 YAP1 inhibitors that target the interaction of YAP1 with OCT4 YAP1, YES1, MYC ALDH1A1 3176/4885HSD17B10 4648/4885HPGD 4716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.